摘要
目的：对糖化血红蛋白、糖化血清蛋白在妊娠糖尿病早期诊断的临床探讨。方法抽取2012年2月～2014年2月本院接诊的336例妊娠期孕妇作为研究对象，按临床诊断将其分为妊娠糖尿病组（GDM组，n=132例）、糖耐量受损组（IGT组，n=85例）及正常对照组（n=119例），比较三组糖筛查结果、糖化血红蛋白（HbA1c）、糖化血清蛋白（GSP）水平及GDM组、IGT组的HbA1c、GSP异常率。结果 GDM组糖筛查结果、HbA1c、GSP水高于IGT、正常对照组，IGT组糖筛查结果、HbA1c、GSP水平高于正常对照组，三组糖筛查结果、HbA1c、GSP水平差异具有统计学意义（P＜0.05）；GDM组HbA1c、GSP异常率明显高于IGT组，差异具有统计学意义（P＜0.05），GDM组、IGT组组内HbA1c、GSP异常率比较差异具有统计学意义（P＜0.05）；HbA1c的正确诊断指数稍高于GSP，GSP检测具有较高的灵敏性，HbA1c检测具有较高的特异性及阳性预测值，但差异无统计学意义（P＞0.05）。结论糖化血红蛋白、糖化血清蛋白在妊娠糖尿病的早期诊断方面具有重要的应用价值。
Objective To analyze the clinical application of glycated hemoglobin, glycated serum protein in the early diagnosis of gestational diabetes. Methods 336 cases of pregnant women during pregnancy from February 2012 to February 2014 in our hospital were randomly selected as research objects, according to the clinical diagnosis, they were divided into gestational diabetes group (GDM group,n=132), impaired glucose tolerance group (IGT group, n=85) and normal control group (n=119). The glucose screening, HbA1c, GSP levels in serum in three groups and the ab-normal rate of GSP, HbA1c in GDM group, IGT group were compared. Results The glucose screening, HbA1c, GSP levels in serum of GDM were higher than that of IGT and normal control group, the glucose screening, HbA1c, GSP levels in serum of IGT were higher than that of nor-mal control group, the differences of three groups were statistically significant (P<0.05); The HbA1c、GSP abnormal rate of GDM group was higher than that of IGT, the differences were sta-tistically significant (P<0.05), the abnormal rate of HbA1c、GSP in each group by chisquare test had statistical significance(P<0.05); The correct diagnosis index of HbA1c was a little higher than GSP, the GSP test had high sensitivity, HbA1c test had high specificity and positive predictive value, but there was no significant difference (P>0.05). Conclusion Glycosylated haemoglobin and glycosylated serum protein has important clinical application value in the early diagnosis of gesta-tional diabetes.
出处
《现代诊断与治疗》
CAS
2014年第16期3603-3605,共3页
Modern Diagnosis and Treatment
关键词
糖筛查试验
妊娠期糖尿病
糖化血红蛋白
糖化血清蛋白
Glucose screening test
Gestational diabetes
Glycated hemoglobin
Glycated serum protein
