摘要
由活性氧(Reactive oxygen species,ROS)引起的氧化应激是胚胎发育受阻的主要原因之一。氧化应激能通过氧化细胞内核酸、蛋白质、脂质等生物分子而导致细胞的衰老或者死亡。在体外受精(In vitro fertilization,IVF)和胚胎体外培养等辅助生殖过程中降低氧化应激是非常重要的。在另一方面,ROS在细胞信号转导中发挥重要作用,也是细胞正常生理活动所必需的。基于ROS的这种双重作用,很难解决由其引起的氧化应激现象。本文对ROS在卵子发生和胚胎发育过程中作用机制的研究进展作一综述。
Oxidative stress caused by elevated reactive oxygen species(ROS)is one of the predominant causes of both male and female infertility.Oxidative stress conditions cause either cell death or senescence by oxidation of cellular molecules including nucleic acid,proteins,and lipids.It is particularly important to minimize oxidative stress when in vitro fertilization is performed for the purpose of assisted reproduction.On the other hand,the beneficial roles of ROS,such as intracellular signaling,have become evident.The antithetical functions of ROS make it more difficult to overcome the problems caused by oxidative stress.This paper summarizes the research progress of the mechanism of action of ROS in oogenesis and in the process of embryonic development.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2014年第7期1038-1043,共6页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金(31360546)
吉林省科技厅重点项目(20100228)
