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中性粒细胞/淋巴细胞比值与结直肠癌临床病理特征的关系 被引量：5

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摘要 目的探讨术前外周血中性粒细胞与淋巴细胞比值(neutrophil to 1ymphocyte ratio,NLR)与结直肠癌临床病理特征的关系。方法回顾分析宁夏医科大学总医院住院的326例结直肠癌患者的临床及病理资料。分析不同TNM(tumor node metastasis)分期患者术前外周血中性粒细胞计数(N),淋巴细胞计数(L)以及NLR的变化趋势。根据NLR将全部病例分为低NLR组(NLR<2)和高NLR组(NLR≥2),比较两组间的临床病理参数,分析NLR与患者临床病理特征的关系。结果术前IV期患者N值、NLR值高于I期、II期、III期患者(P均<0.05)、而L值低于其他3组(P<0.05)。低NLR组和高NLR组患者在年龄、肿瘤部位、癌性梗阻、根治切除、肿瘤最大径、肿瘤形态、肿瘤组织学、浸润深度、淋巴结转移、远处转移及TNM分期比较差异均有统计学意义(P均<0.05)。结论结直肠癌患者术前NLR高提示肿瘤分化较差、存在淋巴结转移或远处转移、分期偏晚,因此可将其作为肿瘤术前评估及治疗方式选择的一项指标。
作者 庄肃非 孟光冉 王恩龙 付琦 李海 杨银学
机构地区 宁夏医科大学 宁夏医科大学总医院结直肠外科
出处 《宁夏医科大学学报》 2015年第10期1210-1212,共3页 Journal of Ningxia Medical University
关键词 结直肠癌 中性粒细胞与淋巴细胞比值 TNM分期
分类号 R735.34 [医药卫生—肿瘤]
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参考文献11

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宁夏医科大学学报
2015年 第10期

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