摘要
目的研究高血压对心肌梗死患者凝血功能、斑块稳定性及心脑血管事件的影响。方法回顾性研究2011年3月至2015年9月我院收治的146例心肌梗死患者的临床资料,按照是否伴有高血压分为观察组(伴有高血压,n=57)和对照组(不伴有高血压,n=89),统计两组患者D二聚体(D-D)和血浆纤维蛋白原(Fbg)水平,颈总动脉、颈总动脉分叉处斑块发生率及斑块类型,比较两组患者颈动脉斑块大小、厚度及血管中膜厚度及心脑血管事件发生情况。结果观察组Fbg、D-D水平与对照组比较均显著较高(P<0.05)。观察组颈总动脉及分叉处斑块检出率均显著高于对照组(73.68%、14.04%VS 26.97%、2.23%);低回声斑块观察组与对照组比较显著较高(42.11%VS 26.97%)(P<0.05)。观察组斑块大小、厚度及血管内中膜厚度与对照组比较明显较大(P<0.05)。观察组心脑血管事件发生率73.68%与对照组26.97%比较差异显著(P<0.05)。结论合并高血压的心梗患者因血液高凝状态显著,斑块稳定性差,发生心脑血管事件几率显著较高。
Objective To explore the effects of associated hypertension on coagulation function,plaque stability and cardio-cerebrovascular events in patients with myocardial infarction. Methods The clinical data of 146 cases of patients with myocardial infarction treated in our hospital from March 2011 to September 2015 were analyzed retrospectively. They were divided into the observation group( with hypertension,n =57) and the control group( without hypertension,n = 89) according to whether or not accompanied by hypertension. The levels of D-dimer( D-D) and plasma fibrinogen( Fbg),the incidence rate of plaque in common carotid artery and crotches of common carotid artery and types of plaques in the two groups were statistically analyzed. The size,thickness of carotid plaques,thickness of tunica media and incidence of cardio-cerebrovascular events were compared between the two groups. Results The levels of Fbg and D-D in the observation group were significantly higher than the control group( P < 0. 05). Plaque detection rate in common carotid artery and its bifurcations of the observation group were significantly higher than the control group( 73. 68%,14.04% VS 26. 97%,2. 23%); hypoechoic plaque in the observation group was significantly higher than the control group( 42. 11% VS 26. 97%)( P < 0. 05). The size,thickness of carotid plaque and thickness of tunica media in the observation group were significantly bigger compared with the control group( P < 0. 05). The incidence of cardio-cerebrovascular events in the observation group was 73. 68% while in the control group was26. 97%( P < 0. 05). Conclusion Incidences of cardio-cerebrovascular events of patients with myocardial infarction combined with hypertension are significantly higher because of significant high blood coagulation state and poor plaque stability.
出处
《血栓与止血学》
2016年第5期505-506,510,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
高血压
心肌梗死
凝血功能
斑块稳定性
Hypertension
Myocardial infarction
Coagulation function
Plaque stability
