摘要
目的研究急性心肌梗死(AMI)老年患者行瑞替普酶和替罗非班联合治疗对起效时间、血液相关指标及微循环的影响。方法资料选取本院2014年6月至2016年3月收治的AMI 102例老年患者予以回顾性地分析,按照治疗时所用不同治疗方案分成2组,将行单纯瑞替普酶治疗45例患者设为对照组,将在对照组治疗基础上行替罗非班治疗57例患者设为观察组,对两组起效时间、不良反应、血液相关指标和微循环情况进行对比。结果观察组起效时间(0.68±0.32)h比对照组(1.36±0.60)h短(P<0.05),两组总不良反应率对比无明显差异(P>0.05);观察组在两组治疗后血液相关指标和微循环指标(AUC、PI、QTd间期)均改善基础上,其改善幅度均比对照组显著(P<0.05)。结论AMI老年患者行瑞替普酶和替罗非班联合治疗效果显著,能够缩短溶栓起效时间,促进患者血液相关指标与微循环指标改善,不良反应少。
Objective To study the acute myocardial infarction( AMI) for elderly patients with reteplase and tirofiban combined treatment effect on the onset time and the related index of blood and microcirculation. Methods Analysis of data in our hospital from June 2014 to March 2016 were AMI in 102 cases of elderly patients,according to treatment with different treatment plan will be divided into 2 groups,treated with reteplase treatment in 45 cases as the control group,the treatment in the control group on the basis of tirofiban treatment of 57 cases of patients as the observation group,to compare the onset time of the two groups,the adverse reaction and related indexes of blood and microcirculation. Results The onset time of the observation group( 0. 68 ± 0. 32) h than the control group( 1. 36 ± 0. 60) H( P < 0. 05),two groups of the total rate of adverse reactions was no significant difference( P > 0. 05); in the observation group after the treatment in the two groups of related index of blood and microcirculation indexes( AUC,PI,QTd interval) on the basis of the improvement,improvement rate than the control group( P < 0. 05). Conclusion Elderly patients with AMI and tirofiban combined with reteplase thrombolytic treatment effect significantly,can shorten the onset time,improve the related indexes of blood and microcirculation index,less adverse reaction.
出处
《血栓与止血学》
2017年第1期45-48,共4页
Chinese Journal of Thrombosis and Hemostasis
关键词
急性心肌梗死
替罗非班
瑞替普酶
微循环
Acute myocardial infarction
Tirofiban
Reteplase
Microcirculation
