摘要
中国心血管疾病的患病率及病死率逐年上升,严重威胁公众健康。目前有研究认为多种心血管疾病可能与自身免疫失衡有关,其中T细胞的活化起到了关键作用。细胞程序性死亡受体-1/程序性死亡受体1配体-1(PD-1/PD-L1)信号通路作为负性调节通路,被证实介导T细胞功能抑制和耗竭,维持机体免疫自稳。随着其基础研究的不断深入,也被认为与多种心血管疾病密切相关,现就PD-1/PD-L1信号通路近期研究热点及其与心血管系统疾病相关性进行归纳。
In recent years,the prevalence rate and death rate of cardiovascular disease have been increasing year by year in China,and seriously threatening the public health. Emerging evidence indicate that cardiovascular disease may be related to autoimmune,in which T cell activation plays critical roles. Programmed cell death 1(PD-1) as a negative synergistic stimulus molecule,and its ligand 1(PD-L1)can be potent inhibitory signals,which can mediate the function of T cells to maintain the autoimmune stability. While the basic research of this pathway has been deepened,it is also believed to play an important regulatory role in cardiovascular diseases. In this paper,we will discuss the recent progress of PD-1/PD-L pathway and the relationship with cardiovascular disease.
作者
代晶晶
木胡牙提
DAI Jingjing;MUHUYATI(Heart International Medicine Center,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)
出处
《心血管病学进展》
CAS
2019年第2期204-208,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81560062)
