摘要
目的:探讨滤泡性淋巴瘤(FL)患者治疗前18F-FDG PET/CT最大标准摄取值(SUVmax)的预后价值。方法:回顾性分析2005年11月至2013年10月在我院经病理确诊的30例FL患者的病例资料及所有患者于治疗前行18F-FDG PET/CT检查结果,并从病理分级、国际预后指数2的分级、有无肿块及骨髓受累,临床检测指标及治疗转归方面评估,治疗前SUVmax与预后因子、近期疗效及远期生存之间的关系。结果:组织学分为1级、2级和3级患者间的SUVmax差异有统计学意义(P=0.040);滤泡性淋巴瘤国际预后指数2(follicular lymphoma international prognostic index,FLIPI2)低危组、中危组和高危组患者的SUVmax差异无统计学意义(P=0.431)。有、无大肿块及有、无骨髓受累患者的SUVmax差异均无统计学意义(均P>0.05);SUVmax与分期、β2微球蛋白、血红蛋白含量、LDH及Ki-67均无相关性(均P>0.05)。完全缓解与未完全缓解患者的SUVmax、有效患者(完全缓解+部分缓解)与无效患者(疾病稳定+疾病进展)的SUVmax差异均无统计学意义(均P>0.05)。分别设定10、15为SUVmax界限值,SUVmax低者与高者的完全缓解率、总有效率、3年PFS率及3年OS率均无统计学意义(均P>0.05)。结论:FL患者治疗前18F-FDG PET/CT的SUVmax预测预后的价值在本组研究中不明确,目前尚不能通过其来判断患者预后。
Objective: To determine the prognostic value of maximum standard uptake( SUVmax) of pretreatment18F-FDG PET /CT scan in newly diagnosed follicular lymphoma( FL). Methods: The clinical data and detection results of 18F-FDG PET /CT scan of 30 patients with FL before treatment from November 2005 to October 2013 were analyzed retrospectively. The relation of SUVmax with prognostic factors,therapeutic efficacy and survival time was evaluated in term of pathologic grade,FLIPI2 absence and presence of bulky disease and bone marrow involvement,clinical indicators and outcome of treatment. Results: There was significant differences of SUVmax among pathological grade 1,grade2 and grade 3( P = 0. 040),but no significant difference was found among FLIPI 2 low risk group,intermediate risk group and high risk groups( P = 0. 431). No difference of SUVmax was observed in patients with and without bulky disease,or with and without bone marrow involvement( both P > 0. 05). SUVmax was not related with such patient characteristics as stage,β2-microglobulin level,hemoglobin content,lactate dehydrogenase and Ki-67( both P > 0. 05). And the difference of SUVmax was no significant for patients with complete remission( CR) and non-CR,or with efficacy and no efficacy( both P > 0. 05). With the cutoff values of 10 and 15,the CR rate,overall response rate,3-year progressionfree survival( PFS) rate and 2-year overall survival( OS) rate were not different between the patients with SUVmax below and above cut-off value( both P > 0. 05). Conclusion: In our study the prognostic value of SUVmax on PET /CT is indeterminate,and it can not be used to predict the FL patients prognosis.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2015年第5期1331-1335,共5页
Journal of Experimental Hematology
