摘要
骨髓增生异常综合征(myelodysplastic syndromes,MDS)是一组以一系或多系骨髓病态造血及外周血细胞减少和高风险向白血病进展为特征的造血系统恶性克隆性疾病。MDS常伴有多种染色体畸变,染色体畸变在MDS的发病、诊断及预后评估中有重要的意义。约一半的MDS都有染色体畸变,以非平衡异常为主,不同的染色体畸变类型预示不同的转归。染色体平衡易位虽然发生率相对较低,但似乎伴平衡易位的患者较其他核型异常患者更易向急性白血病转化。本文就MDS的染色体畸变在诊断和预后中的意义做一综述。
Myelodysplastic syndromes( MDS) are a group of clonal hematopioetic disorders characterized by myelodysplasia,decreased peripheral blood cells and high-risk of transformation into acute leukemia. MDS are often accompanied by a variety of chromosomal aberrations which play a role in disease pathogenesis,and are crucial in diagnosis and prognostic evaluation of this disease. About half of the patients with MDS have chromosomal abnormalities,mainly unbalanced chromosomal aberration. Different chromosomal aberration types are associated with different clinical outcome of this disease. Though balanced chromosomal translocations are not common in MDS,it seems that the patients with them have a higher leukemia transformation rate than those with other type of chromosomal aberrations. In this review,the chromosomal aberrations in MDS and their clinical significance for diagnosis and prognosis are briefly summarized.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2015年第5期1509-1512,共4页
Journal of Experimental Hematology
关键词
骨髓增生异常综合征
染色体畸变
染色体平衡易位
myelodysplastic syndrome
chromosomal aberration
balanced chromosoma translocation
