摘要
目的:观察及评价托吡酯对各型癫痫的临床疗效及安全性。方法:对2000年1月至2002年12月在该院确诊的105例癫痫患者中的72例采用托吡酯添加治疗、33例单药治疗,经8周加量期和12周稳定期观察后进行评价。结果:添加治疗组及单药治疗组总有效率分别为72.2％和84.8％,完全控制率分别为27.8％和45.5％。无明显不良反应。结论:托吡酯是一种广谱、有效及安全的新型抗癫痫药。
Objective: TO observe and evaluate the clinical efficiency and safety of topiramate for treatment of patients with various types of epilepsy. Methods: 105 patients suffering from epilepsy were treated with topiramate, of them 72 cases received a topiramate add-on therapy and 33 cases a monotherapy. The efficiency and side effects were evaluated after 8 weeks titration period and 12 weeks stabilization period. Results: The total effective rate was 72.2%and 84.8% in add-on group and monotherapy group respectively. The seizure free rate was 27.8% and 45.5% in two groups respectively.Side effects were generally mild. Conclusions: Topiramate is a highly effective and safe antiepileptic drug.
出处
《岭南急诊医学杂志》
2003年第4期264-266,共3页
Lingnan Journal of Emergency Medicine
