摘要
目的 研究基质金属蛋白酶 9(MMP 9)在慢性肝病患者肝纤维化过程中的表达和动态变化。方法 用酶标法检测 75例慢性乙型病毒性肝炎和 40例乙肝后肝硬化患者血清中MMP 9浓度。结果 血清MMP 9浓度在慢性肝病患者肝纤维化过程中逐渐升高 ,与正常对照组比较有显著性意义 (P <0 .0 1) ;其中轻度患者的MMP 9与中度、重度、肝硬化之间 ,肝硬化与中度、重度之间两两比较有显著性差异 (P <0 .0 5或P <0 .0 1)。结论 血清MMP 9在慢性肝病患者肝纤维化过程中可能起促进作用 。
ObjectiveTo investigate the dynamic change and expression of Matrix Metalloproteinase-9(MMP-9) in patients with ch ronic hepatitis B(CHB) and liver cirrhosis(LC).MethodsSerum MMP -9 was detected by ELISA in 75 patients with CHB and 40 patients with LC and 2 0 healthy persons.ResultsSerum MMP-9 increased in CHB and LC.There were significan t differences between patients with chronic liver disease and control group ( P<0.01).MMP-9 levels in severe degrees of CHB and LC were higher than those in mild and moderate degrees of CHB(P<0.05/0.01) and seru m MMP-9 levels in LC were notably higher than those in severe degrees of CHB to o.ConclusionSerum MMP-9 levels increase in CHB and LC.It may par ticipate in the development of hepatic fibrosis and can be used as diagnostic in dex for hepatic fibrosis in chronic liver diseases.
出处
《胃肠病学和肝病学杂志》
CAS
2003年第6期578-579,共2页
Chinese Journal of Gastroenterology and Hepatology
