摘要
目的 :了解 1998～ 2 0 0 2年广州地区淋球菌对 5种抗生素的耐药性的变迁及产青霉素酶淋球菌(PPNG)和高水平耐四环素淋球菌 (TRNG)的流行状况。方法 :用琼脂稀释法测定最低抑菌浓度 (MIC)以及用纸片碘量法检测β-内酰胺酶。结果 :60 3株淋球菌检出 PPNG 64株 (10 .6% )、TRNG 83株 (13 .7% ) ,1998～ 2 0 0 2年 ,PPNG、TRNG流行率及环丙沙星耐药率 ,经μ检验 ,P<0 .0 1,差异有显著性。头孢曲松、壮观霉素未发现耐药菌株 ,壮观霉素抗菌活性最强。结论
Objective:To survey the resistance var ia tion and the epidemic profile of penicillinase-producing Neisseria gonorrhoea (P PNG) and tetracycline resistant Neisseria gonorrhoea(TRNG).Methods: The minimum inhibitory concentrations(MIC) were determined using the agar di lution method and β-lactamase was detected with the paper iodin quantitative m ethod.Results:Of 603 strains of Neisseriae gonorrhoeae are 64(1 0 6%) PPNG strains and 83(13 7%) TRNG strains.The prevalent rates of PPNG and TRNG and the resistance rate of ciprofloxacin in 1998 show a notable difference from those in 2002 (analyzed with μ examination,P<0 01).The resistance str ain has not been found to either ceftriaxone or specitinomycin,however,the later shows stronger antimicrobial activity.Conclusion:The successiv e surveillance on resistance of Neisseriae gonorrhoeae is of great importanc e.
出处
《中国微生态学杂志》
CAS
CSCD
2003年第6期359-360,共2页
Chinese Journal of Microecology
