摘要
目的 了解不同阶段肝硬变患者血浆内皮素 (ET)水平 ,探讨其对肝硬变腹水形成和肝肾功能损伤所起的作用。方法 用放射免疫法测定血浆ET 1浓度 ,同时也了解肝肾功能。结果 血浆ET 1在无腹水组、有腹水组和肾衰组均明显高于正常对照组。肾衰组与有腹水组 (无肾衰 )比较差异有显著性。有腹水组和无腹水组差异无显著性。血浆ET随肝功能损伤加重而逐渐升高。结论 血浆ET升高可能在肝硬变病程的进展中起了重要作用 。
Objective To detect plasma endothelin(ET) levels in cirrbosis patients with different course and study its roles in ascitic fluid production, hepatic injury and renal failure. Methods The plasma ET 1 concentration was detected with radioimmunoassay. The liver function were measured with common methods. Results The plasma levels of ET 1 were significantly higher in the three cirrbotic groups than in healthy examination subjects and higher in patients with functional renal failure than that without the failure. But no significant difference was observed between patients with and without ascitic fluid. EE 1 levels increased gradually in relation to the stat of hepatic injury. Conclusion Increased plasma ET 1 may play important roles in cirrbosis procession and may be important factors in ascite fluid production, hepatic injury and renal failure.
出处
《安徽医科大学学报》
CAS
2003年第6期445-447,共3页
Acta Universitatis Medicinalis Anhui
关键词
血浆
内皮素
病程
腹水
肝硬化
endothelins/blood
liver cirrhosis/bood
liver cirrhosis/ etiology
