摘要
目的 :探讨联合应用长短效吗啡制剂对癌痛患者生活质量的影响。方法 :随机将 93例中 -重度晚期癌痛患者分为 3组 ,分别给予吗啡即释片、吗啡控释片和联合治疗 ,观察对各种生活质量指标的影响。结果 :疼痛控制的有效率为控释片组 86 2 % ,联合治疗组 85 2 % ,即释片组 88 0 % ,3组间无显著性差异 (P >0 0 5 )。 3组患者治疗前和治疗后d14的生活质量指标比较 ,除睡眠情况明显改善 (P <0 0 0 1)外 ,其余指标治疗前后均无显著性差异 (P >0 0 5 )。联合治疗组和控释片组的治疗后的睡眠评分均明显高于即释片组 (P <0 0 5 ) ,而联合治疗组和控释片组的治后睡眠评分无显著性差异 (P >0 0 5 )。结论 :长短效吗啡制剂联合应用方案对晚期癌痛的持续控制和生活质量的提高均优于吗啡即释片组 ,与价格较高的控释片组方案相近 。
Objective:To assess the impact of administration of controlled-plus immediate-release morphine on the life quality of cancer pain patients. Methods: 93 patients with chronic, median to severe cancer pain were randomized into three groups, administering controlled-plus immediate-release morphine or controlled-release morphine or immediate-release morphine, and completed the life quality questionnaire before and during the treatment, respectively. Results: There were no significant differences between the three groups in pain relief rate (86.2% vs. 85.2% vs. 88.0%, P>0.05). There was a significant difference in lack of sleep between before treatment and 14 days after treatment in each group, and there was no difference in other life quality factors. The uninterrupted sleep rate in Group A and Group B was significantly lower than that in Group C. Conclusion: The regimen of controlled- plus immediate-release morphine is recommended for patients with chronic severe cancer pain and financial problems, because of the advantage of continued pain relief, enhanced life quality and economy.
出处
《中国药物依赖性杂志》
CAS
CSCD
2003年第4期272-275,共4页
Chinese Journal of Drug Dependence
