摘要
目的 以参麦注射液为工具药验证扶正护脑法治疗缺血性中风急性期的临床疗效并探讨其可能的作用机理 ,为扶正护脑法的确立奠定临床基础。方法 将 6 0例急性缺血性中风患者随机分为治疗组 (4 0例 )和对照组 (2 0例 ) ,分别给予参麦注射液和尼莫地平注射液进行治疗。结果 参麦注射液能明显减轻中风急性期患者神经功能缺损程度 ;抑制白介素 - 1β(IL 1β)、白介素 - 6(IL 6 )等炎性介质的异常升高 ;降低血浆内皮素 (ET) ,升高降钙素基因相关肽 (CGRP) ,恢复两者的平衡 ,从而改善血管舒缩功能 ,临床总有效率达 90 % ,明显高于对照组 (P <0 0 5 )。结论 参麦注射液治疗缺血性中风急性期取得了较好的临床疗效 ,表明以扶正护脑法作为缺血性中风急性期的基础治疗方法是可行的 ,值得推广。
Objective The curative effect and mechanism of the therapy of strengthening the genuine and protecting the brain to treatment of acute ischemic stroke with Shenmai Injection were studied. Method Sixty cases suffered from acute ischemic stroke were divided randomly into the treatment group (40 cases) and the control group (20 cases) and treated with Shenmai Injection or nimodipine respectively. Result Shenmai Injection could obviously reduce the damage degree of nervous function in acute stroke cases, control the abnormal raise of IL_1β, IL_6, regain the balance between ET and CGRP by decreasing ET or increasing CGRP, and improve the systolic and diastolic function of the heart. The total curative effective rate was 90% which significantly higher than that of the control group ( P <0 05). Conclusion Shenmai Injection has good curative effect to acute ischemic stroke, which indicates that it is feasible to popularize to take the therapy of strengthening the genuine and protecting the brain as a basic treatment on acute ischemic stroke.
出处
《北京中医药大学学报（中医临床版）》
2003年第3期7-10,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家中医药管理局立项 (中医药科 :0 0 0 1LP0 6号 )
正大青春宝药业有限公司资助课题
关键词
扶正护脑法
药物治疗
缺血性中风
急性期
中医药疗法
参麦注射液
the therapy of strengthening the genuine and protecting the brain
Shenmai Injection
acute ischemic stroke
