摘要
目的 探讨植物雌激素—大豆异黄酮对人子宫内膜腺上皮细胞增殖的影响。方法 应用MTT比色方法研究大豆异黄酮对人子宫内膜腺上皮细胞增殖的影响。结果 低浓度 (0 0 0 0 5～ 0 0 5mg/L)时 ,随着剂量的增加表现出刺激子宫内膜增殖的作用。高浓度 (0 0 5～ 5mg/L)时 ,随着剂量的增加大豆异黄酮刺激子宫内膜增殖的幅度下降。结论 大豆异黄酮能起到促进子宫内膜细胞增殖的作用 。
Objective To explore the proliferation of human endomethial glandular epithelial cells induced by phytoestrogen-soy isoflavone .Methods MTT assay was adopted to determine the proliferation.Results At lower concentration(0.0005～0.05mg/L),soy isoflavone stimulated the proliferation of endometrium with the increasing of concentration.At higher concentration(0.05～5mg/L),the effects of proliferation deceased with the increasing of concentration.Conclusions Soy iso flavone can induce the proliferation of endometrium,thus it can play an important role in maintaining the function of internal secretion of endometrium.
出处
《锦州医学院学报》
2003年第5期24-25,60,共3页
Journal of Jinzhou Medical College
