摘要
目的 探讨生长激素(GH)预处理对卵巢低反应(POR)患者体外受精(IVF)治疗结局的影响。方法 回顾性分析136例POR患者,其中107例行组间对照,29例行自身对照;分别组间对照比较和自身对照比较促性腺激素(Gn)的使用总量、天数及临床效果。结果 组间对照中预处理组Gn的使用总量和使用天数明显减少,其胚胎数、优质胚胎数、移植率、生化妊娠率、临床妊娠率明显升高,差异均有统计学意义(P<0.05);但其获卵数差异无统计学意义(P>0.05)。自身对照组应用GH预处理后不但Gn的使用时间与总量减少,而且获卵数、胚胎数、优质胚胎数、移植率、生化妊娠数、临床妊娠数均升高,差异有统计学意义(P<0.05)。结论 GH预处理可明显提高POR患者IVF的临床结局,并明显减少Gn的使用总量和天数。
Objective To investigate the effect of growth hormone(GH)preconditioning on the outcome of in vitro fertilization treatment in patients with poor ovarian response(POR).Methods Data of 136 patients with POR,including 107 cases of intergroup control and 29 cases of self-control,were retrospectively analyzed.The total amount and days of Gn administration and its clinical effects were compared between two groups.Results In intergroup control group,the total amount and days of Gn administration were significantly decreased,and the number of embryos,the number of high-quality embryos,transplantation rate,biochemical pregnancy rate and clinical pregnancy rate were significantly increased in patients treated with GH preconditioning,with statistically significant differences(P<0.05);however,there was no significant difference in the number of retrieved oocytes between two groups(P>0.05).In the self-control group,the total amount and days of Gn administration were significantly decreased,and the number of retrieved oocytes,the number of embryos,the number of high-quality embryos,transplantation rate,the number of biochemical pregnancy and clinical pregnancy were significantly increased after treatment with GH preconditioning,with statistically significant differences(P<0.05).Conclusion For POR patients undergoing in vitro fertilization,GH preconditioning may significantly improve the clinical outcome of in vitro fertilization,and reduce the total amount and days of Gn administration.
作者
葛小花
王建业
张雅梦
章志国
郑贤芳
周平
曹云霞
Ge Xiaohua;Wang Jianye;Zhang Yameng(Reproductive Medicine Center,Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei230022;Dept of Obstetrics and Gynecology,Chaohu Affiliated Hospital of Anhui Medical University,Chaohu238000;Anhui Province Key Laboratory of Reproductive Health and Genetics,Anhui Medical University,Hefei230022;Biopreservation and Artificial Organs,Anhui Provincial Engineering Research Center,Hefei230022)
出处
《安徽医科大学学报》
CAS
北大核心
2019年第8期1291-1295,共5页
Acta Universitatis Medicinalis Anhui
基金
国家重点研发计划生殖健康及重大出生缺陷防控研究重点专项项目(项目编号:2017YFC1002000)
关键词
卵巢低反应
生长激素
预处理
治疗结局
poor ovarian response
growth hormone
preconditioning
treatment outcome
