摘要
目的探究不同纤维取向心包组织压缩后的力学性能,评估对经导管瓣膜耐久性的影响。方法将心包条分为横、纵、斜向的心包条各12组,每组中包含3条,其中1条不压缩,另外两条分别在12.5、25 N下压缩1 h。利用单轴拉伸方法对压缩后的心包进行测试,分析其力学性能的变化。结果不同纤维取向心包在压缩前后均表现出明显的各向异性。压缩前后的割线模量、弹性模量以及极限拉伸强度,总体上都表现为纵向>斜向>横向。纵、斜向牛心包在25 N压缩后的平均拉伸强度比值分别为0.92和0.87,压缩前后的拉伸强度比值均有显著性差异(P<0.05)。横向牛心包25 N压缩后的平均拉伸强度比值为0.97,压缩前后的拉伸强度比值无显著性差异(P>0.05)。结论不同纤维取向心包在低应力、短时间下压缩损伤都很小。在经导管瓣膜的设计和制造过程中,应该充分考虑心包纤维取向和压缩后强度变化对瓣膜性能的影响。
Objective To investigate the mechanical behavior of bovine pericardium with different orientations after compression and evaluate its effects on the duration of transcatheter aortic valve.Methods According to the fiber directions,the pericardial strips were divided into 12 groups of transverse,longitudinal and oblique pericardial strips,and each group included 3 strips of pericardium.One strip maintained the original state,and the other two strips were under 12.5 N and 25 N compression,respectively for 1 h.The mechanical properties of compressed samples were tested and analyzed subsequently in uniaxial tension test.Results The samples with different orientations showed obvious anisotropy before and after compression.The secant modulus,elastic modulus and ultimate tensile strength of the longitudinal pericardium were generally greater than those of the oblique pericardium,while the oblique pericardium was larger than the transverse pericardium.For longitudinal and oblique bovine pericardium under 25 N compression,the average tensile strength ratio was 0.92 and 0.87,respectively,and the ratio of tensile strength before and after compression had a significant difference(P<0.05).The average tensile strength ratio of transverse bovine pericardium after 25 N compression was 0.97,and there was no significant difference in the ratio of tensile strength before and after compression(P>0.05).Conclusions The compressive damage of the pericardia with different fiber orientations was very small under low stresses at transitory time.For design and production of transcatheter aortic valves,the orientations of the pericardium and the changes of strength after compression should be taken into consideration.
作者
吴泽斌
金昌
王丽珍
唐笑兰
钟生平
樊瑜波
WU Zebin;JIN Chang;WANG Lizhen;TANG Xiaolan;ZHONG Shengping;FAN Yubo(Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China;Beijing Advanced Innovation Centre for Biomedical Engineering,Beihang University,Beijing 102402,China;KingstronBio(Changshu)Co],Ltd],Changshu 215500,Jiangsu,China)
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2019年第1期21-26,共6页
Journal of Medical Biomechanics
基金
国家重点研发计划重点专项子课题(2016YFC1102202)
关键词
牛心包
经导管瓣膜
压缩
耐久性
bovine pericardium
transcatheter aortic valve
compression
duration
