摘要
目的:探讨单硝酸异山梨酯应用于心力衰竭治疗的临床效果及对患者心功能的影响。方法:选取2017年6月-2018年6月笔者所在医院收治的心力衰竭患者60例为研究对象,随机分为研究组与对照组。对照组患者给予常规β受体阻滞剂、醛固酮受体拮抗剂、利尿剂等基础治疗,研究组在对照组的基础上给予单硝酸异山梨酯治疗。对比两组治疗效果、治疗前后血清细胞因子水平变化[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]、心功能指标(心脏指数(CI)、左室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]变化,并观察不良反应发生情况。结果:与对照组对比,研究组患者的总有效率明显升高(P<0.05)。治疗前,两组患者TNFα、IL-6、hs-CRP水平比较差异无统计学意义(P>0.05),治疗后,两组患者的TNFα、IL-6、hs-CRP水平均较治疗前明显降低,且研究组明显低于对照组(P<0.05)。治疗前,两组患者CI、LVEDD、LVEF值比较差异无统计学意义(P>0.05);治疗后两组患者CI、LVEF值均较治疗前明显升高,LVEDD值较治疗前降低,且研究组均优于对照组(P<0.05)。两组患者在治疗期间均未发生严重的不良反应。结论:在常规治疗的基础上应用单硝酸异山梨酯治疗心力衰竭可有效提高临床效果,改善心功能,减轻炎症反应,且安全性高,值得临床推广。
Objective:To investigate the clinical efficacy of Isosorbide Mononitrate in the treatment of heart failure and its effect on cardiac function.Method:A total of 60 patients with heart failure admitted to our hospital from June 2017 to June 2018 were randomly divided into study group and control group.The patients in control group were given basic treatment such as routine beta blocker,aldosterone receptor antagonist and diuretic.The patients in study group were given Isosorbide Mononitrate on the basis of control group.The therapeutic effect and serum cells before and after treatment were compared between the two groups.Changes of serum cytokine levels such as tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),cardiac function levels such as cardiac function index(CI),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and adverse reactions were observed.Result:Compared with the control group,the total effective rate of the study group was significantly higher(P<0.05).Before treatment,there were no significant differences in the levels of TNF-α,IL-6 and hs-CRP between the two groups(P>0.05).After treatment,the levels of TNF-α,IL-6 and hs-CRP in the two groups were significantly lower than those before treatment,and which in the study group were significantly lower than those in the control group(P<0.05).Before treatment,there were no significant differences in CI,LVEDD and LVEF between the two groups(P>0.05).After treatment,the CI and LVEF of the two groups were significantly higher than those before treatment,and the LVEDD of the two group were lower than those before treatment,and the indexes were superior than those of the control group(P<0.05).There were no serious adverse reactions in the two groups during treatment.Conclusion:Isosorbide Mononitrate can effectively improve the curative effect,improve cardiac function and alleviate inflammation in the treatment of heart failure on the basis of routine treatment.It is safe and worthy of clinical promotion.
作者
郭文安
陈津瀚
黄上萌
GUO Wen’an;CHEN Jinhan;HUANG Shangmeng(The First Affiliated Hospital of Xiamen University,Xiamen 361003,China)
出处
《中外医学研究》
2019年第25期17-19,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
心力衰竭
单硝酸异山梨酯
细胞因子
心功能
临床疗效
Heart failure
Isosorbide mononitrate
Cytokines
Cardiac function
Clinical efficacy
