摘要
目的:探讨妊娠期碘营养状态与甲状腺功能关系。方法:选取2016年12月-2018年8月笔者所在医院收治的96例妊娠期妇女为研究对象,按照碘营养状态的不同分为三组,观察组(碘适量,尿碘150~499μg/L)、对照1组(碘缺乏,尿碘<150μg/L)、对照2组(碘过量,尿碘>499μg/L),选择全自动化学发光免疫分析仪检测,且对检测后游离甲状腺素、促甲状腺素及甲状腺功能异常发生率、甲状腺过氧化物酶抗体阳性率进行观察及评估。结果:观察组游离甲状腺素含量高于对照1组、对照2组,对照1组游离甲状腺素高于对照2组、促甲状腺素含量低于对照2组,差异均有统计学意义(P<0.05);观察组与对照1组促甲状腺素含量比较差异无统计学意义(P>0.05);观察组及对照1组促甲状腺素含量均低于对照2组,差异均有统计学意义(P<0.05)。观察组甲状腺功能异常发生率低于对照1组、对照2组,对照1组发生率低于对照2组,差异均有统计学意义(P<0.05)。观察组甲状腺过氧化物酶抗体阳性率低于对照1组、对照2组,对照1组阳性率低于对照2组,差异均有统计学意义(P<0.05)。结论:碘缺乏或碘过量是妊娠期间最为常见现象,需通过维持适量的碘水平达到降低甲状腺功能异常的目的。
Objective:To investigate the relationship between iodine nutritional status and thyroid function during pregnancy.Method:Ninety-six pregnant women admitted to the hospital from December 2016 to August 1818 were enrolled in the study.They were divided into three groups according to the different iodine nutritional status.The observation group(iodine iodine,urinary iodine 150-499μg/L),control group 1(iodine deficiency,urinary iodine<150μg/L),control group 2(iodine excess,urinary iodine>499μg/L).Fully automatic chemiluminescent immunoassay was selected,and the incidence of abnormal thyroid and thyroid function and positive rate of thyroid peroxidase antibody were observed and evaluated.Result:The content of free thyroxine in the observation group was higher than that in the control group 1 and 2,while the content of free thyroxine in the control group was higher than that in the control group 2 and thyrotropin was lower than that in the control group 2(P<0.05).There was no significant difference in thyrotropin content between observation group and control group 1(P>0.05),but the content of thyrotropin in observation group and control group 1 was lower than that in control group 2(P<0.05).The proportion of thyroid dysfunction in the observation group was lower than that in the control group 1 and 2,and the incidence of the control group was lower than that of the control group(P<0.05),the differences were statistically significant(P<0.05).The positive rate of thyroid peroxidase antibody in the observation group was lower than that in the control group 1 and 2,and the positive rate in control group 1 was lower than that in control group 2,the differences were statistically significant(P<0.05).Conclusion:Iodine deficiency or iodine excess is the most common phenomenon during pregnancy.It is necessary to reduce the thyroid dysfunction by maintaining an appropriate amount of iodine.
作者
温陈媛
游育东
杨晓霞
吴永和
陈舒恬
WEN Chenyuan;YOU Yudong;YANG Xiaoxia(The Second Hospital of Longyan,Longyan 364000,China)
出处
《中外医学研究》
2019年第25期171-173,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
妊娠期
碘营养状态
甲状腺功能
Pregnancy
Iodine nutritional status
Thyroid function
