摘要
Objective:In this paper,we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island.Methods:We tested the Taq IB and I405 V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package(Version 19.0).Results:Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P<0.001.Further analysis implied that genotypes B1B1(P<0.001,OR=0.148,95% CI=0.095-0.230) and VV(P<0.001 and OR=0.353,95% CI=0.237-0.525) were significantly different between centenarians and matched controls.The combination of B and V,such as B1B1-II(P<0.001,OR=0.128,95% CI=0.049-0.329),B1B1-IV(P<0.001,OR=0.115,95% CI=0.056-0.237),B1B2-VV(P<0.05,OR=0.534,95% CI=0.310-0.920),and B2B2-VV(P<0.001,OR=0.198,95% CI=0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan.Conclusion:Our results implied that allele B1B1 and VV,as well as the combination B1B1-II,B1B1-IV,B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan,south of China.
Objective: In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island. Methods: We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0). Results: Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P<0.001. Further analysis implied that genotypes B1B1 (P<0.001, OR=0.148, 95% CI=0.095-0.230) and VV (P<0.001 and OR=0.353, 95% CI=0.237-0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P<0.001, OR=0.128, 95% CI=0.049-0.329), B1B1-IV (P<0.001, OR=0.115, 95% CI=0.056-0.237), B1B2-VV (P<0.05, OR=0.534, 95% CI=0.310-0.920), and B2B2-VV (P<0.001, OR=0.198, 95% CI=0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan. Conclusion: Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.
基金
supported by the National Science Foundation of China(No.31501018 and 81260510)
social development project of Hainan Province (SF201401)
