摘要
双氢青蒿素作为青蒿素的重要衍生物,是我国自行研制出的抗疟新药。近些年来,人们对双氢青蒿素进行了多方面的研究,在抗肿瘤研究方面有许多新进展,发现其诱导肿瘤细胞凋亡的机制与多条信号通路有关,例如PI3K/Akt、MAPK、STAT3、Wnt/β-catenin、NF-κB等信号通路。通过对作用机制的深入研究和阐述有望发现双氢青蒿素的新适应症,使其在临床上的应用更加广泛。
Dihydroartemisinin is not only an important derivative of artemisinin but also a new antimalarial drug developed by China.In recent years,more and more studies had been conducted on dihydroartemisinin,especially on the research of anti-tumor effects and mechanism,which were deeply related to tumor cell apoptosis signal pathways,involving PI3 K/Akt signaling pathway,MAPK signaling pathway,STAT3 signaling pathway,Wnt/β-catenin signaling pathway,NF-κB signaling pathway and so on.The more studies and clarification of dihydroartemisinin on anti-tumor mechanism,the more indications are going to be found,making it more widely used in clinic.
作者
梁小娜
单淇
周福军
徐旭
侯文彬
LIANG Xiaona;SHAN Qi;ZHOU Fujun;XU Xu;HOU Wenbin(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Tianjin Pharmaceutical Research Institute,Tianjin 300193,China;State Key Laboratory of Drug Release Technology and Pharmacokinetics,Tianjin 300193,China;Tianjin Key Laboratory of Quality Markers for Traditional Chinese Medicine,Tianjin 300193,China;National and Local Joint Engineering Laboratory for Modern Preparation and Quality Control of Traditional Chinese Medicine,Tianjin 300193,China)
出处
《药物评价研究》
CAS
2019年第4期775-780,共6页
Drug Evaluation Research
基金
国家新药创制项目(2017ZX09101002-001-005)
关键词
双氢青蒿素
肿瘤
细胞凋亡
信号通路
dihydroartemisinin
tumor
apoptosis
signaling pathway
