摘要
目的建立ICP-MS法测定茯苓中砷(As)、铍(Be)、镉(Cd)、钴(Co)、铜(Cu)、锰(Mn)、钼(Mo)、镍(Ni)、铅(Pb)、锑(Sb)、硒(Se)、钛(Ti)、铊(TI)、钒(V)、铬(Cr)、锌(Zn)、汞(Hg)共17种金属元素的含量,并对不同产地的11批茯苓的金属元素含量进行评价。为中药材生产中的质量控制和临床上的安全用药提供了科学依据。方法样品经微波消解处理后,以Se、Y、In、In-1、Bi为内标,采用ICP-MS法同时进行测定。结果对于各测定元素,标准曲线的相关系数r>0.998,回收率在88.0%～107.3%,RSD值在0.1%～11.0%。结论该方法简便、快速、准确,可用于茯苓中药材中17种元素的含量测定。
Objective The Chinese herbal medicine Poria as the research object,the determination of arsenic in Poria ICP-MS method(As),beryllium(Be),cadmium(Cd),cobalt(Co),copper(Cu),manganese(Mn),molybdenum(Mo),nickel(Ni),lead(Pb),antimony(Sb),selenium(Se),titanium(Ti),thallium(TI)and vanadium(V),chromium(Cr),zinc(Zn),mercury(Hg)content of 17 kinds of metal elements,and the content of metal elements in different places of the 11 batch of Poria was evaluated.It provides a scientific basis for quality control and clinical safety in the production of Chinese medicinal materials.Methods An Inductivety Coupled Plasma—Mass Spectrometry method with Microwave-Assisted Digestion was developed with Se,Y,In,In-1 and Bi as internal standard.Results For the determination of each element,the correlation coefficients were better than 0.998 0—0.999 9,the recovery values ranged from 88.0%to 107.3%,and the RSD values ranged from 0.1%to 11.0%.Conclusion The method is simple,rapid and accurate,and can be used for the determination of 17 elements in Chinese medicinal materials.
作者
李佳
LI Jia(Huai'an food and drug inspection institute,Huai'an 223005,China)
出处
《药物评价研究》
CAS
2019年第5期890-894,共5页
Drug Evaluation Research
