摘要
目的探讨百令胶囊联合醋酸泼尼松对肾病综合征患者肾功能及脂质代谢紊乱的影响。方法按随机数字表法将2016年2月—2017年5月接诊的96例肾病综合征患者分为对照组和观察组,每组48例。对照组采用醋酸泼尼松治疗,观察组在此基础上给予百令胶囊。连续用药6个月后,比较两组肝功能[血尿素氮(BUN)、血浆白蛋白(ALB)、血肌酐(SCr)]、脂质代谢[高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、胆固醇(TC)]、24 h尿蛋白水平以及临床疗效。结果治疗后,两组BUN、ALB、SCr水平较治疗前具有显著改善(P<0.05),且观察组BUN、SCr水平低于对照组,ALB水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组HDL-C水平显著升高,LDL-C、TG、TC水平均显著降低(P<0.05);且观察组HDL-C水平高于对照组,LDL-C、TG、TC水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组24 h尿蛋白水平均明显下降(P<0.05),且观察组24 h尿蛋白水平低于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率为95.83%,明显高于对照组的81.25%,差异具有统计学意义(P<0.05)。结论对肾病综合征患者采用百令胶囊、醋酸泼尼松联合治疗,能改善肾功能和脂质代谢紊乱,降低24 h尿蛋白水平,提高临床疗效。
Objective To investigate the effect of Corbrin capsules combined with prednisone acetate on renal function and lipid metabolism disorder in patients with nephrotic syndrome(NS).Methods 96 NS patients admitted into our hospital from February2016 to May 2017 were divided into two groups by random number table,48 cases in each group.Control group was given prednisone acetate,while experimental group was treated with Corbrin capsules based on control group.After six-month treatment,the liver function[blood urea nitrogen(BUN),albumin(ALB),serum creatinin(SCr)],lipid metabolism[high-density lipoprotein cholesterol(HDL-C),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC)],24 h urinary protein level and clinical efficacy were compared between the two groups.Results The levels of BUN and SCr in experimental group were lower than those in control group,while the level of ALB was higher than control group(P<0.05).The levels of TG,TC,LDL-C in experimental group were lower than those in control group,while the level of HDL-C was higher than control group(P<0.05).The24 h urinary protein of experimental group[(1.46±1.05)g/24 h]was lower than control group[(2.18±1.22)g/24 h](P<0.05).The total effective rate of experimental group(95.83%)was higher than control group(81.25%)(P<0.05).Conclusion Corbrin capsules combined with prednisone acetate in treatment of NS can effectively improve renal function and lipid metabolism disorder,decrease the level of 24 h urinary protein and increase clinical efficacy.
作者
施磊
SHI Lei(Department of Nephrology,Beijing Huairou Hospital,Beijing 101400,China)
出处
《药物评价研究》
CAS
2019年第5期936-939,共4页
Drug Evaluation Research
关键词
肾病综合征
百令胶囊
醋酸泼尼松
脂质代谢紊乱
肾功能
nephrotic syndrome
Corbrin capsules
prednisone acetate
lipid metabolism disorder
renal function
