摘要
循环肿瘤DNA(circulating tumor DNA,ctDNA)是肿瘤细胞在坏死、凋亡后释放的一种游离DNA(cell free DNA,cfDNA),ctDNA的遗传信息与肿瘤保持着高度一致性,能克服常规组织活检所无法突破的肿瘤异质性问题,ctDNA检测可以实时、多次地了解肿瘤的状态。近年来,ctDNA检测在结直肠癌(colorectal cancer,CRC)的早期诊断与筛查、疗效判断与预后评估、耐药监测与用药指导中得到广泛应用。本文就以上几个方面综述ctDNA检测在CRC临床诊疗中的应用进展,以期对CRC患者的临床诊疗认知有所裨益。
Circulating tumor DNA(ctDNA),a kind of cell-free DNA(cfDNA),is released from tumor cells after necrosis or apoptosis. The genetic information of ctDNA is highly consistent with that of tumor,so it can overcome the heterogeneity of tumor which cannot be solved by conventional biopsy of tumor tissue. ctDNA detection can reflect the state of tumor constantly and repeatedly. In recent years,ctDNA detection has been widely used in the early diagnosis and screening of colorectal cancer,the evaluation of curative effect and assessment of prognosis,the monitoring of drug resistance and the guidance of drug use. In this article,the application of ctDNA detection in the clinical diagnosis and treatment of CRC will be reviewed,in order to benefit the clinical diagnosis and treatment of CRC patients.
作者
谢英超
周春莲
徐伟文
XIE Yingchao;ZHOU Chunlian;XU Weiwen(School of Laboratory Medicine and Biotechnology,Southern Medical University,Guangzhou,Guangdong,China,510515)
出处
《分子诊断与治疗杂志》
2019年第2期73-78,90,共7页
Journal of Molecular Diagnostics and Therapy
基金
2017年度大学生创新创业训练计划省级项目(No.201712121118)
关键词
结直肠癌
液体活检
肿瘤标志物
循环肿瘤DNA
临床应用
Colorectal cancer
Liquid biopsy
Tumor marker
Circulating tumor DNA
Clinical application
