摘要
目的了解玉溪地区高敏肌钙蛋白T(high sensitive cardiac troponin-T,hs-cTnT)在普通人群中的分布特点。方法以玉溪市人民医院2017年7月至10月的1 594例18～89岁健康体检者为研究样本,对hs-cTnT在普通健康人群检出率、分布特点及与常规生化指标的相关性进行统计分析。结果 (1)hs-cTnT在普通健康人群检出率为57.31%,其中男性的检出率是74.52%,女性的检出率是23.75%;(2)普通健康人群中男性的hs-cTnT平均水平为(5.59±5.08)ng/L,女性为(3.46±1.45)ng/L,男性与女性hs-cTnT水平有统计学差异(P<0.05),各年龄段hs-cTnT水平比较男性均高于女性;(3)hs-cTnT水平随年龄增长而增大,男性和女性66岁以上人群与其它各年龄组人群的hs-cTnT水平比较均有统计学差异(P<0.05);(4)hs-cTnT与年龄和肾功能指标尿素(urea nitrogen,Urea)、肌酐(creatinine,Crea)尿酸(uric acid,UA)呈明显正相关。结论 hs-cTnT存在性别和年龄的分布差异,应建立不同性别、不同年龄的参考区间;56岁以下女性hs-cTnT检出率较低,将其作为心脑血管疾病早期筛查和监测的指标意义有限。
Objective To understand the distribution characteristics of highly sensitive cardiac troponin-T(hs-cTnT)in the general population in Yuxi area. Methods A total of 1 594 healthy people aged 18-89 years old from July to October 2017 in Yuxi People.s Hospital were selected as samples to study the detection rate and distribution characteristics of hs-cTnT in the general healthy population. The detection rate, distribution characteristics and correlation with routine biochemical indicators of hs-c TnT were analyzed. Results(1) The detection rate of hs-cTnT was 57.31% in the general healthy population,74.52% in males and 23.75% in females.(2) The average level of hs-cTnT was(5.59±5.08)ng/L in males and(3.46±1.45)ng/L in females. There was significant difference between males and females(P < 0.05). The level of hs-cTnT in males was higher than that in females in all age groups.(3) The level of hs-cTnT increased with age. There were significant differences in the levels of hs-cTnT between aged over 66 in both males and females and other groups(P<0.05).(4) hs-c TnT was positively correlated with age and renal function indicators such as urea nitrogen(Urea),creatinine(Crea)and uric acid(UA). Conclusion There is a difference in gender and age distribution between hs-cTnT,and reference intervals of different genders and ages should be established. Since the detection rate of hs-cTnT is lower in women under 56 years old,It has limited significance as an indicator for early screening and monitoring of cardiovascular and cerebrovascular diseases.
作者
叶丹
冯磊
吴英松
YE Dan;FENG Lei;WU Yingsong(Institute of Antibody Engineering,School of Laboratory and Biotechnology,Southern Medical University,Guangzhou,Guangdong,China,510515;Laboratory Department of the Sixth Affiliated Hospital of Kunming Medical University,Yuxi,Yunnan,China,653100)
出处
《分子诊断与治疗杂志》
2019年第2期141-145,共5页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金项目(81460326)
关键词
高敏肌钙蛋白T
分布特点
早期筛查
High sensitive cardiac troponin-T
Distribution characteristics
Early screening
