摘要
目的:利用循证医学方法探讨消旋卡多曲辅助治疗轮状病毒肠炎的安全性及有效性。方法:检索Pubmed、Web of Science、Embase、中国知网、维普及万方数据库,检索时间为2008年至2017年。利用Revman 5.3软件对纳入的文献进行Meta分析。结果:纳入26篇文献包含27个随机对照研究。Meta分析显示以消旋卡多曲作为辅助治疗的方案能提高有效率及显效率(P<0.01)。添加消旋卡多曲辅助治疗的方案可缩短症状缓解、呕吐缓解、大便次数及性状恢复时间,并可缩短治疗周期。安全性分析显示,在对症治疗的基础上增加消旋卡多曲并未增加不良反应(P=0.73)。结论:在对症治疗的基础上增加消旋卡多曲辅助治疗小儿轮状病毒肠炎安全、有效。
Objective To explore the safety and efficacy of racecadotril in the adjuvant treatment of rotavirus enteritis by evidence-based medicine.Methods The electronic databases including Pubmed,Web of Science,Embase,CNKI,VIP and Wanfang were systematically searched from 2008 to 2017.Revman 5.3 software was used for the meta analysis of the included literature.Results A total of 26 literatures were included,including 27 randomized controlled studies.Meta-analysis showed that the use of racecadotril as an adjunct therapy improved the efficiency and obvious efficiency(P<0.01).The addition of racecadotril adjuvant therapy can reduce symptom relief,vomiting relief,stool frequency and trait recovery time,and shorten the treatment cycle.Safety analysis showed that the addition of racecadotril on the basis of symptomatic treatment did not increase adverse reactions(P=0.73).Conclusion On the basis of symptomatic treatment,it is safe and effective to add racecadotril as an adjuvant therapy for pediatric rotavirus enteritis.
作者
许金云
赵琰
顾教伟
XU Jin-yun;ZHAO Yan;GU Jiao-wei(Department of Pediatrics,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《湖北医药学院学报》
CAS
2019年第3期246-252,共7页
Journal of Hubei University of Medicine
