摘要
近年的研究发现 ,心境障碍患者在脑、神经细胞和信号分子水平都存在异常。边缘 丘脑 皮质环路和边缘 皮质 纹状体 苍白球 丘脑环路参与了心境障碍行为的发生 ,这些部位的糖代谢和脑血流量、皮质容量、神经元和胶质细胞的数量和形态均发生改变 ,同时心境障碍患者脑内磷酸肌醇环路、Wnt信号通路和神经营养因子下游信号转导通路也有相应变化。
The recent investigations of mood disorders have found there are abnormalities from brain to cell and singal transduction pathways. The limbic-thalamic-cortical and limbic-cortical-striatal pallidal thalamic circuits are involved in the mood disorder behaviors. The carbohydrate metabolism and cerebral blood flow, gray matter volumes, the number and morphology of neurons and glial cells in these areas are changed. Besides, there are disorders in the phosphoinositol cycle, the wingless (Wnt) signaling pathway and neurotrophic signal transduction cascades in the brain of mood disorders.
关键词
心境障碍
神经生物学
神经营养因子
信号转导
发病机制
mood disorder
limbic-thalamic-cortical circuit
limbic-cortical-striatal-pallidal-thalamic circuit
neuron
glial cell
signal transduction
