摘要
目的 :探讨在不同剂量农用混合稀土常乐的作用下 ,大鼠肝脏酶活性的变化及作用机理。方法 :以 Wis-tar大鼠为研究对象 ,连续用生理盐水和 2 0 .0、 5 .0、 2 .0 m g· kg- 1 常乐灌胃 3个月 ,每日 1次。应用酶组织化学技术 ,观察大鼠肝脏的琥珀酸脱氢酶 (SDHase)、葡萄糖 6磷酸酶 (G- 6 - Pase)及三磷酸腺苷酶 (Ca2 + - ATPase)的变化。结果 :与对照组比较 ,5 .0和 2 .0 m g· kg- 1 组酶活性颗粒变化不明显 ,2 0 .0 m g· kg- 1 组 SDHase、 G- 6 -Pase和 Ca2 + - ATPase酶活性颗粒均明显减少。结论 :给予不同剂量的混合稀土常乐 ,对大鼠肝脏酶活性有影响 ,其中以 2 0 .0 mg· kg- 1
Objective\ To study the effects of different dose Changle on enzymatic activity of rat liver Methods\ 120 healthy Wistar rats were divided into three experimental groups of different doses (2 0,5 0, 20 0 mg·kg -1 Changle) and the control group were given physiological saline,one time a day respectively, and lasted for 3 months The changes of SDHase,G 6 Pase, and Ca 2+ ATPase in rat livers were observed by histochemical technique.Results\ Comparing with the control group,the levels of SDHase, G 6 Pase, and Ca 2+ ATPase in hepatocytes in the group of 20 0 mg·kg -1 were reduced obviously Conclusion\ Changle can have an effect on rat hepatic enzymatic activity with the dose of 20 0 mg·kg -1
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2004年第1期20-22,共3页
Journal of Jilin University：Medicine Edition
基金
国家自然科学基金资助课题 (2 9890 2 80 )
