1[1]Wang EA,Rosen V,DAlessandro JS,et al.Recombinant human bone morphogenetic protein induces bone formation[J].Proc Natl Acad Sci USA,1990,87:2220~2224.
2[2]Sandhu HS,Kanim LEA,Kabo JM,et al.Effective doses of recombinant bone morphogenetic protein-2 in experimental spinal fusion[J].Spine,1996,211:5~22.
3[3]Martin GJ,Boden SD,Morone MA,et al.Posterolateral intertransverse process spinal arthrodesis with rhBMP-2 in a nonhuman primate:Important lessons learned regarding dose,carrier,and safety[J].J Spinal Disord,1999,12:179~189.
4[4]David SM,Gruber HE,Meyer PA,et al.Lumbar Spinal fusion using recombinant human bone morphogenetic protein in the canine:A comparison of three dosages and two carriers[J].Spine,1999,24:1973~1981.
5[5]Hecht BP,Fischgrund JS,Herkowitz HN,et al.The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interboby fusion modak[J].Spine,1999,24:629~637.
6[6]McKay W,Sandhu HS.RhBMP-2 use in spinal fusions:Focus issue on bone morphogenetic proteins in spinal fusion[J].Spine,2002,27(Suppl 16S):S66~S85.
7[7]Ebendal T,Bengtsson H,Soderstrom S.Bone morphogenetic proteins and their receptors:Potential functions in the brain[J].J Neurosci Res,1998,51:139~146.
8[8]Postacchini F,Cinotti G.Bone regrowth after surgical decompression for lumbar spinal stenosis[J].J Bone Joint Surg Br,1992,74:862~869.
9[9]Boden SD,Martin GJ,Monroe MA,et al.Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein-2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate[J].Spine,1999,24:1179~1186.
10[10]Meyer RA.Ir,Gruber HE,Howard BA,et at.Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog[J].Spine,1999,24:747~754.
3Urist MR. Bone formation by autoinduction. Science, 1965,150:893-899.
4Asahina I, Sampath TK, Hauschka PV. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res, 1996,222:38-47.
5Vaccaro AR, Patel T, Fischgrund J, et al. A pilot safety and efficacy study of OP-1 putty(rhBMP-7) as an adjunct to lilac crest autograft in posterolateral lumbar fusions. Eur Spine J,2003,12:495-500.
6McGee MA, Findlay DM, Howie DW, et al. The use of OP-1 in femoral impaction grafting in a sheep model. J Orthop Res,2004,22 : 1008-1015.
7Bomback DA, Grauer JN, Lugo R, et al. Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model. Spine, 2004,29 : 1612-1617.
8Vacearo AR, Patel T, Fischgrund J, et al. A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine, 2004,29:1885-1892.
9Boden SD, Zdeblick TA, Sandhu HS, et al. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans:a preliminary report. Spine, 2000,25:376-381.
10Govender PV, Rampersaud YR, Rickards L, et al. Use of osteogenic protein-1 in spinal fusion: literature review and preliminary results in a prospective series of high-risk cases.Neurosurg Focus, 2002,13(6) :e4.