摘要
目的 研究静脉注射甘露醇对血脑屏障的影响。方法 长耳白兔 ,随机分组 ,戊巴比妥钠静脉麻醉。不同时间顺序给予伊文思蓝和甘露醇注射液。10 %的甲醛局部灌注固定 ,取脑。定性、定量判定伊文思兰渗透情况。结果 甘露醇组的脑切片有明显的伊文思蓝脑组织中渗透。不同时间点伊文思蓝的渗透情况显示静脉推注甘露醇后 10 m in,伊文思蓝渗透明显 ,30 min渗透减弱 ,6 0 min后几乎没有渗透。
Objective To verify the effects of mannitol on osmotic opening of blood brain barrier by peripheral intravenous infusion. Methods Rabbits were anesthetized with 3% sodium pentobarbital 30mg/kg,iv.Evans blue and mannitol were given in different time points respectively,and then the brains of these rabbits had been given regional perfusion fixation. With quantity and quality examination of Evans blue osmosis into brain, the effects of mannitol in opening blood brain barrier (BBB) had been evaluated Results There was a remarkable extravasated dye in the brain sections of rabbit group C and rabbit group B 10min ,group B 30min.Conclusion Mannitol peripheral intravenous infusion can temporarily and osmoticallyopen blood brain barrier.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2003年第4期350-352,共3页
Journal of Apoplexy and Nervous Diseases
