摘要
目的 研究血管内皮生长因子 (VEGF)、碱性成纤维细胞生长因子 (bFGF)、转化生长因子 β1 (TGF β1 )及其受体和肿瘤源性粘附因子 (TAF)在胶质瘤中的表达特点 ,以及它们与肿瘤内微血管密度的关系。方法 应用免疫组化和形态计量方法检测 92例胶质瘤微血管密度 (MVD)、VEGF、bFGF、TGF β1 及其受体和TAF的表达。结果 92例胶质瘤中 ,VEGF/KDR阳性 6 8例 (73 9% ) ,bFGF/FGFr阳性 6 2例 (6 7 4 % ) ,TGF β1 /TGF β(RI)阳性 5 8例 (6 3 0 % ) ,TAF阳性 5 3例 (5 7 6 % )。血管生成因子与其受体表达具有一致性 ,并与MVD值显著相关。结论 VEGF、bFGF、TGF β1 和TAF是胶质瘤中血管生成的重要因子 。
Objective To investigate the expression of vascular endothelial cell growth factor(VEGF),basic fibroblast growth factor(bFGF),transforming growth factor β 1(TGF β 1)and tumor derived adhesion factor(TAF) in Gliomas and its relation to neovasculariztion and of the disease.Methods The intratumoral microvessel density(MVD) and expression of VEGF,bFGF,TGF β 1 and TAF were determined with immunohistochemistry and morphometry in 92 cases of laryngopharyngeal malignant melanoma.Results Of the 28 cases,68 were strong positive for VEGF/KDR(73.9%),62 for bFGFr(67.4%),58 for TGF β 1/TGFβ(RI)( 63.0% )and for TAF(57.6%) respectively.The expression of the angioenic factors was coordinated with that of their receptors and significantly correlated with MVD.Conclusion All the four factors are involved in the angiogenesis of gliomas.
出处
《重庆医学》
CAS
CSCD
2004年第1期63-64,共2页
Chongqing medicine
