摘要
目的 :研究纤溶酶原激活物和抑制物在子宫颈癌的发生、发展及侵袭转移过程中的规律及对临床的指导意义。方法 :采用ELISA法检测 4 2例子宫颈癌患者和 10例良性子宫肿瘤患者的血浆和组织中uPA和PAI 1含量 ,按良恶性、手术前后、临床分期和组织类型等分别进行对照分析。结果 :子宫颈癌患者血浆中uPA和PAI 1含量随临床分期的升高逐渐增加。宫颈癌患者血浆uPA和PAI 1含量术后显著降低。淋巴结转移组血浆uPA含量高于无转移组。癌组织中的uPA和PAI 1含量高于癌周组织。正常宫颈、宫颈上皮内瘤变、宫颈鳞癌组织uPA含量呈上升趋势。腺癌的组织uPA含量高于鳞状细胞癌组 ,PAI 1含量无差异。结论 :检测宫颈癌患者uPA和PAI 1含量可能对其侵犯范围、盆腔淋巴结转移情况。
Objective To investigate the significance of the expression of urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in plasma and tissue in occurrence,progression and invasion in cervix carcinomas.Methods The levels of uPA and PAI-1 in plasma and tissue was detected by ELISA in 42 cases of cervix carcinoma and 10 cases of benign uterine tumor as control.The differences were compared in benign and malignant diseases,before and after operations,clinical stages and pathologic types.Results The levels of uPA and PAI-1 in plasma of cervical carcinomas were obviously higher than those of control group.They descended after radical surgery.Compared with the group of no pelvic lymph node metastasis,the serous uPA levels of pelvic lymph node metastasis group was obviously higher,P<0.05.The levels of uPA and PAI-1 in cancer tissues were higher than those in tissues beside carcinomas.Compared with normal cervix,the level of uPA in cervical intraepithelial neoplasm and squamous cervical carcinomas was significantly different.The level of uPA in adenocarcinomas was higher than that in squamous carcinomas.Conclusions Monitoring the levels of uPA and PAI-1 in cervical carcinomas may evaluate the extent of cancer invasion, lymph node metastasis and prognosis.
出处
《肿瘤防治杂志》
2003年第8期821-824,共4页
China Journal of Cancer Prevention and Treatment
