摘要
目的探讨乳腺癌组织P-gp、C-erbB-2和p53蛋白的表达及其相关性。方法采用免疫组织化学LSAB法检测151例乳腺癌石蜡包埋组织和40例乳腺正常组织的P-gp、C-erbB-2和p53蛋白表达水平,并将结果与临床病理资料结合起来进行分析。结果在151例乳腺癌组织中P-gp阳性62例(40.8%),40例对照组P-gp阳性1例(2.5%),两组间差异有显著性(x2=21.27,P<0.01);C-erbB-2阳性101例(66.9%),对照组C-erbB-2表达阴性0例(0%),两组间差异有显著性(x2=56.78,P<0.01);p53阳性69例(45.7%),对照组p53表达阴性0例(0%)阴性,两组间差异有显著笥(x2=28.61,P<0.01);C-erbB-2(x2=12.43,γ=0.30,P<0.01)和p53(x2=19.12,γ=0.37,P<0.01)蛋白表达与P-gp表达呈正相关。结论乳腺癌组织C-erbB-2、p53可能诱导P-gp表达上调。
Objective:To investigate the relationship of P-glycoprotein expression with expression of C-erbB-2and p53in human breast carcinoma. Methods: Immunohistochenical essay using the LSAB immunostaining technique was used to study protein expression of P-gp、C-erbB-2 and p53 respectively on the specimens of paraffin-embedded tissues in 151 cases of human breast carcionma and 40 normal breast tissues as control. Results:The expression of P-gpwere found in 62 (40.8%)of breast carcinoma and in 1(2.5%) of control samples. The difference between the two groups was statistically significant (x2=21.27,P<0.01).The expression of C-erbB-2were found in 101(66.9%)of breast carcinomas and in 0(0%)of control samples.The difference between the two groups was statistically significant(χ2=56 78,P<0 01).The expression of p53 were found in 69(45.7%)of breast carcinomas and in 0(0%)of control samples.The difference between the two groups was statistically singificant (χ2=28 61,P<0 01).The expression of C-erbB-2 (χ2=12 43,γ=0.30,P<0 01)and P53(χ2=19 12,γ=0.37,P<0 01)were correlated with the positive immunohistochemical reaction of P-gp protein.Conclusion:The expression of C-erbB-2 and P53 may induce and elevate the expression of P-gp in breast carcinomas tissues.
出处
《井冈山医专学报》
2004年第1期1-3,共3页
Journal of Jinggangshan Medical College
