摘要
目的探讨奥氮平联合前列地尔注射液治疗伴发精神障碍急性脑梗死患者临床疗效和安全性。方法将2010年3月~2014年3月就诊的80例伴发精神障碍急性脑梗死患者按照随机分配的原则分为观察组和对照组,各40例,对照组患者给予常规治疗方案,观察组患者给予奥氮平联合前列地尔注射液治疗,治疗2个月,比较两组患者的治疗效果和精神症状改善情况。结果观察组的总有效率为80.0%(32/40),明显高于对照组[50.0%(20/40)](P<0.05);同时与对照组比较,观察组的医疗保健评分、精神症状评分明显降低,总的睡眠评分明显延长,差异均有统计学意义(P<0.05)。结论伴发精神障碍急性脑梗死患者应用前列地尔注射液联合奥氮平治疗可获得肯定的临床疗效;不仅可明显提高临床的总有效率,且提高患者的睡眠质量,更能使相关症状显著得到缓解。
Objective To study the clinical efficacy and safety olanzapine combined with alprostadil treatment of acute cerebral infarction patients with psychiatric disorders. Methods Eighty acute cerebral infarction patients with psychi-atric disorders from March 2010 to March 2014 were randomly allocated in accordance with the principle of divided into observation group and control group,40 patients in each group. The patients in control group were given conven-tional treatment scheme for two months,patients in the observation group was given olanzapine combined with al-prostadil injection treatment for two months. The treatment effects and mental symptom of the two groups were com-pared. Results The total effective rate of observation group was 80.0%(32/40),which was significantly higher than the control group 50.0% (20/40), there was statistically significant difference between the two groups (P<0.05).The obser-vation group score(psychiatric symptoms, medical care) was significantly lower than that of the control group, while the effective sleep time was significantly longer than that of the control group, there was statistically significant difference between the two groups (P<0.05). Conclusion The clinical curative effect of olanzapine combined with alprostadil treatment of acute cerebral infarction patients with psychiatric disorders is accurate, not only can improve the clinical total effective rate of treatment, and can significantly alleviate the symptoms, improve the quality of sleep.
出处
《中国现代医生》
2014年第35期45-47,共3页
China Modern Doctor
关键词
奥氮平
前列地尔
急性脑梗死
精神障碍
Olanzapine
Alprostadil
Acute cerebral infarction
Psychiatric disorders
