摘要
目的 总结成人多形性胶质母细胞瘤 (GBM )的疗效 ,判定影响预后的相关因素 ,初步建立GBM预后的分级系统。方法 回顾研究手术治疗的 171例多形性胶质母细胞瘤患者的临床资料并根据随访 ,采用Kaplan meier法计算生存率 ,绘出生存曲线 ;Logistic回归分析判定影响预后的因素。根据多因素分析结果 ,建立GBM预后的分级系统。 结果 Logistic多因素回归分析显示病人的年龄、Karnofsky行为等级 (KPS)评分、手术切除范围和术前影像学显示的肿瘤坏死程度等是多形性胶质母细胞瘤重要的预后不利因素。通过以上四种因素建立的GBM分级系统表明 :分值越高 ,生存时间越短 ,分值与预后明显相关。结论 初步建立的GBM分级系统对判定患者的预后有一定指导作用。
Objective To evaluate the curative effect, to determine the adverse factors of prognosis, and to establish elementary clinical progrostic scale for patients with glioblastoma multiforme(GBM).Methods One hundred seventy one consecutive patients with histologically proven GBM who underwent tumor resection were retrospectively analyzed. Survival rate was calculated with Kaplan-Meier method, and logistic regressive analysis was done to identify adverse prognostic factors. According to the result of multivariate regressive analysis, was clinical progrostic scale was established. Results Logistic multivariate regressive analysis revealed that age, Karnofsky performance scale(KPS) score, extent of resection, and the degree of necrosis on preoperative imaging studies were adverse factors for prognosis. Hereby was clinical progrostic scale established, which revealed that scale correlated with prognosis. Conclusion Clinical progrostic scale indicate prognosis of patients with GBM.
出处
《肿瘤》
CAS
CSCD
北大核心
2004年第1期71-72,共2页
Tumor
