摘要
目的:探讨普米克令舒雾化吸入对儿童哮喘的治疗效果及对IL-1β和IL-12水平的影响。方法:选取2012年1月~2013年10月哮喘患儿168例,对照组82例采用常规治疗,观察组86例在常规治疗基础上应用普米克令舒雾化吸入治疗。观察两组疗效、主要症状、体征、气道阻力并测定IL-1β和IL-12水平。结果:观察组治愈率为75.59%,高于对照组的62.20%(P<0.05);观察组咳嗽、喘息和肺内哮鸣音评分为(3.04±0.03)分、(3.11±0.03)分和(3.12±0.04)分,明显低于对照组(P<0.05);治疗后观察组气道阻力为(1.74±0.11)kPa/L、低于对照组(2.28±0.14)kPa/L(P<0.05);两组治疗后IL-1β和IL-12均低于治疗前(P<0.05);观察组治疗后IL-1β和IL-12分别为(19.18±1.39)ng/L和(23.38±2.04)ng/L,均低于对照组的(34.26±1.42)ng/L和(46.27±2.16)ng/L(P<0.05);Western blot检测发现,普米克令舒组IL-1β和IL-12灰度值分别为0.354±0.059,0.579±0.051,与哮喘组相比具有统计学差异(P<0.05)。结论:普米克令舒雾化吸入治疗儿童哮喘具有显著的临床效果,并可减低患儿血清中IL-1β和IL-12水平。
Objective: To explore the curative effect of aerosol inhalation of Pulmicort respulas in treatment of childhood asthma and its impact on IL- 1β and IL- 12 levels. Methods: A total of 168 children with asthma were selected from January 2012 to October2013,and then they were divided into control group and observation group,82 children in control group were treated with conventional therapy,while 86 children in observation group were treated with conventional therapy combined with aerosol inhalation of Pulmicort respulas. The curative effects,main symptoms,signs and airway resistances in the two groups were observed; the levels of IL- 1β and IL- 12 were measured. Results: The cure rate in observation group was 75. 59%,which was statistically significantly higher than that in control group( 62.20%)( P <0.05); the scores of cough,wheezing and buzzing in the lungs in observation group were( 3.04 ±0.03),( 3.11 ±0.03)and( 3. 12 ± 0. 04),respectively,which were statistically significantly lower than those in control group( P < 0. 05); after treatment,the airway resistance in observation group was( 1. 74 ± 0. 11) kPa /L,which was statistically significantly lower than that in control group( 2.28 ±0.14 kPa/L)( P <0.05); IL-1β and IL-12 levels in the two groups after treatment were statistically significantly lower than those before treatment( P < 0. 05); IL- 1 β and IL- 12 levels after treatment in observation group were( 19. 18 ± 1. 39) ng /L and( 23.38 ±2.04) ng/L,respectively,which were statistically significantly lower than those in control group( 34.26 ±1.42 ng/L)( 46.27 ±2. 16 ng /L)( P < 0. 05); western blot showed that gray values of IL- 1β and IL- 12 in observation group were( 0. 354 ± 0. 059) and( 0.579 ±0.051),respectively,compared with control group,there were statistically significant differences( P < 0.05). Conclusion:The clinical effect of aerosol inhalation of Pulmicort respulas is significant in treatment of childhood asthma,and Pulmicort respulas can reduce serum levels of IL- 1β and IL- 12.
出处
《中国妇幼保健》
CAS
北大核心
2014年第20期3273-3276,共4页
Maternal and Child Health Care of China
