摘要
干燥综合征是一种炎性细胞侵犯外分泌腺体的慢性自身免疫疾病,口干是其最常见的症状。伴随着干燥综合征患者口腔内微环境的改变,口腔各种微生物之间及微生物与宿主之间的平衡被打破,进而出现口腔微生态失调。口腔微生态失调与自身免疫疾病关系密切,其不仅是疾病所导致的结果,也可能是疾病进一步发展的原因。目前研究认为干燥综合征患者口腔微生态失调与唾液微环境的改变及口腔黏膜免疫受损存在密切的关系,本文对口腔微生态与干燥综合征关系的新近研究进展进行综述。
Sj?gren′s syndrome is a chronic autoimmune disease in which inflammatory cells invade the exocrine glands.Xerostomia is its most common symptom.With the change of the oral microenvironment in patients with Sj?gren′s syndrome,the balance among various microorganisms in the oral cavity and that between the microorganisms and the host are broken,resulting in oral microecological disorders.Oral dysbiosis is closely related to autoimmune diseases.It is not only the result of disease,but also the cause of further development of the disease.The present studies suggest that there is a close relationship between oral dysbiosis and the changes in salivary microenvironment and impaired oral mucosal immunity in patients with Sj?gren′s syndrome.This article will review recent advances in research on the relationship between oral microecology and Sj?gren′s syndrome.
作者
朱丰林
李成荫
ZHU Fenglin;LI Chengyin(Department of Rheumatology,Chongqing Hospital of Traditional Chinese Medicine,Chongqing400021,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第4期471-474,共4页
Chinese Journal of Microecology
基金
国家自然科学基金(81804086)
重庆市基础研究与前沿探索项目(cstc2018jcyjAX0055)
重庆市2018年科卫联合中医药科技项目(ZY201802059)
重庆市中医院院内课题(2016-1-3)
