摘要
目的探讨多西紫杉醇联合奥沙利铂和5-氟尿嘧啶化疗方案治疗进展期胃癌的效果。方法选取2010年1月至2016年4月间江汉大学附属医院武汉市第六医院收治的104例进展期胃癌患者,其中采用多西紫杉醇、奥沙利铂和5-氟尿嘧啶化疗方案治疗的52例患者纳入观察组,采用奥沙利铂和5-氟尿嘧啶化疗方案治疗的52例患者纳入对照组。比较两组患者的近期疗效、1年生存率、2年生存率、中位无进展生存时间、肿瘤进展时间、生活质量评分及不良反应发生率。结果观察组患者客观缓解率为69. 2%,高于对照组的30. 8%,差异有统计学意义(P <0. 05)。观察组患者1年生存率(69. 2%)和2年生存率(46. 2%)均高于对照组(38. 5%和19. 2%),差异均有统计学意义(均P <0. 05)。观察组患者中位无进展生存时间和治疗后3个月生存质量评分均高于对照组,肿瘤进展时间少于对照组,差异均有统计学意义(均P <0. 05)。观察组患者不良反应发生率(50. 0%)和对照组(42. 3%)比较,差异无统计学意义(P> 0. 05)。结论多西紫杉醇、奥沙利铂和5-氟尿嘧啶化疗方案治疗进展期胃癌患者的效果更佳,延长患者生存时间,不会显著增加不良反应发生率。
Objective To explore the efficacy of docetaxel combined with oxaliplatin and 5-fluorouracil in the treatment of advanced gastric cancer. Methods A total of 104 patients with advanced gastric cancer treated at The Sixth Affiliated Hospital of Jianghan University between January 2010 and April 2016 were selected. Fifty-two patients who received docetaxel combined with oxaliplatin and 5-fluorouracil were included in the observation group and 52 patients who received oxaliplatin and 5-fluorouracil were included in the control group. The short-term efficacy,1-year survival,2-year survival,median progression-free survival,time to tumor progression,quality of life score and incidence of adverse reactions were compared between the two groups. Results The objective remission rate was 69. 2% in the observation group which was higher than 30. 8% of the control group( P < 0. 05). The 1-year survival rate( 69. 2%) and 2-year survival rate( 46. 2%) in the observation group were higher than in the control group( 38. 5% and 19. 2%,respectively)( both P < 0. 05). The median progression-free survival and the quality of life at 3 months after treatment were higher in the observation group than in the control group( all P < 0. 05). Time to tumor progression was less in the observation group than in the control group( P < 0. 05). There was no significant difference in the incidence of adverse reactionsbetween the observation group( 50. 0%) and the control group( 42. 3%)( P > 0. 05). Conclusion Docetaxel combined with oxaliplatin and 5-fluorouracil is more effective in the treatment of advanced gastric cancer,which help to control the progression of the disease,prolong the survival without significantly increasing the incidence of adverse reactions.
作者
杜娟
余琼
肖曼丽
皮国良
张刚
DU Juan;YU Qiong;XIAO Man-li;PI Guo-liang;ZHANG Gang(Department of Internal Medicine,Hubei University Hospital,Wuhan 430062,China;Department of Gastroenterology,The Sixth Affiliated Hospital of Jianghan University,Wuhan 430015,China;Department of Radiation Oncology,Hubei Cancer Hospital,Wuhan 430079,China)
出处
《中国肿瘤临床与康复》
2019年第3期294-296,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
