摘要
目的观察盐酸羟考酮缓释片(奥施康定)在晚期肿瘤中重度疼痛的治疗效果、不良反应及生活质量改善情况。方法应用盐酸羟考酮缓释片治疗80例晚期肿瘤患者的中重度疼痛,全面评估患者疼痛,确定好初始剂量,根据患者疼痛控制情况调整患者用药剂量,从而达到有效的镇痛效果,并观察患者用药前后生活质量改善情况及用药后患者不良反应的情况。结果 80例晚期肿瘤中重度疼痛患者,最终滴定剂量60-480mg/天,治疗后疼痛评分在3分以下(疼痛达满意控制)的患者71例,占88.7%,经镇痛治疗后患者食欲增加,睡眠明显改善,生活质量提高。在所有不良反应中,便秘最常见(发生率为15.0%),其次是恶心、呕吐、头晕,无呼吸抑制及"成瘾"的发生。结论盐酸羟考酮缓释片在治疗晚期肿瘤中重度疼痛方面安全有效,副作用小,生活质量明显提高,适合慢性癌痛患者长期使用。
Objective To investigate the efficacy,adverse effect,and improvement on quality of life of oxycodone hydrochloride controlled-release tablets(Oxycontin) for the treatment of moderate to severe cancer pain. Methods 80 patients suffering from moderate to severe cancer pain received Oxycontin at an initial dosage. Dose of Oxycontin was adjusted according to the pain score. Their pain scores,quality of life and adverse effects would be reevaluated simultaneously. Results The ultimately daily titrated dosage of Oxycontin ranged from 60 mg to 480 mg. The overall response rate of pain relief was 88. 7% . The analgesia by Oxycontin improved patient’s quality of life significantly. The mainly side effect of Oxycontin was constipation,which could be solved after treatment. Conclusion It could bring significant analgesia and improve the patient’s quality of life to treat moderate to severe cancer pain with oxycodone hydrochloride controlled release tablets,and the side effects were tolerable.
出处
《中国保健营养（下半月）》
2013年第5期1352-1353,共2页
China Health Care & Nutrition
