摘要
目的探索2型糖尿病对细菌性肝脓肿患者感染病情的影响。方法回顾性分析2010年12月-2016年12月于医院接受治疗的114例细菌性肝脓肿患者的临床资料,按照患者是否合并2型糖尿病分为合并组52例和非合并组62例。收集患者入院时的临床表现,记录中性粒细胞比率(NEUT%)、血小板计数(PLT)、白细胞计数(WBC)、白蛋白(ALB)、血红蛋白(Hb)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、二氧化碳结合力(CO_2-CP)等实验室指标,分析两组患者抗菌药物使用情况。结果两组患者临床表现畏寒寒战、发热、乏力、呕吐、恶心、黄疸、肝大等占比比较差异无统计学意义,非合并组临床表现腹痛、肝区压痛和肝区叩痛占比高于合并组(P<0.05)。两组患者WBC、Hb、ALT、AST指标水平比较差异无统计学意义,合并组患者NEUT%高于非合并组(P<0.05);两组患者替考拉宁、氟喹诺酮类、万古霉素抗菌药物使用占比比较差异无统计学意义,合并组患者碳青霉烯类抗菌药物使用占比高于非合并组(P<0.05)。结论 2型糖尿病合并细菌性肝脓肿患者腹痛、肝区压痛、肝区叩痛临床表现发生率低于非合并患者,合并患者NEUT%、PLT、ALB、CO_2-CP等实验室指标变化明显,抗感染治疗同时应该进行相应治疗。
OBJECTIVE To explore the influence of type diabetes mellitus on infection of the patients with bacterial liver abscess.METHODS The clinical data of 114 patients with bacterial liver abscess who were treated in the hospital from Dec 2010 to Dec 2016 were retrospectively analyzed,the patients were divided into the combined group with 52 cases and the non-combined group with 62 cases according to the status of complication with type 2 diabetes mellitus.The clinical manifestations of the patients were collected at the admission,the laboratory test indexes such as percentage of neutrophils(NEUT%),blood platelet(PLT)counts,white blood cell(WBC)counts,albumin(ALB),hemoglobulin(Hb),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and carbon dioxide combining power(CO2-CP)were recorded,and the use of antibiotics of the two groups of patients was observed.RESULTS There were no significant differences in the proportions of patients with the clinical manifestations such as chills,fever,fatigue,vomiting,nausea,jaundice and hepatomegaly.The proportions of the patients with abdominal pain,liver tenderness and percussion pain were significantly higher in the non-combined group than in the combination group(P<0.05).There were no significant differences in the levels of WBC,Hb,ALT and AST between the two groups of patients,and the percentage of neutrophils of the combined group was significantly higher than that of the non-combined group(P<0.05).There were no significant differences in the proportions of patients who used teicoplanin,fluoroquinolones and vancomycin between the two groups,while the proportion of patients who used carbapenems was significantly higher in the combined group than in the non-combined group((P<0.05).CONCLUSION The incidence rates of abdominal pain,liver tenderness and percussion pain are lower in the bacterial liver abscess patients complicated with type 2 diabetes mellitus than in the patients without type 2 diabetes mellitus,the laboratory test indexes such as NEUT%,PLT,ALB and CO2-CP of the patients complicated with type 2 diabetes mellitus change remarkably,and corresponding treatment should be given while the anti-infection treatment is conducted.
作者
马海涛
陈国宙
王煊
刘立刚
霍金鹏
马晓权
MA Hai-tao;CHEN Guo-zhou;WANG Xuan;LIU Li-gang;HUO Jin-peng;MA Xiao-quan(The First People′s Hospital of Lanzhou,Lanzhou,Gansu 730050,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2019年第9期1351-1354,共4页
Chinese Journal of Nosocomiology
基金
甘肃省自然科学基金资助项目(2017WM892)
关键词
2型糖尿病
细菌性肝脓肿
临床特点
抗菌药物
Type 2 diabetes mellitus
Bacterial liver abscess
Clinical characteristic
Antibiotic
