摘要
目的:运用Meta分析的方法系统评价雌激素受体α基因多态性2位点(rs2234693和rs9340799)与男性不育的相关性。方法:检索Pub Med、EMABSE、万方、中国知网等数据库,初筛得到文献24篇,对符合纳入标准的文献使用Stata 11.0软件在4个模型中进行分析,计算优势比值及95%可信区间评价其关联度,并进行敏感性分析及发表偏倚的评估。结果:共纳入6篇病例-对照研究,包括774名患者和841名健康对照者。Meta分析结果显示rs2234693基因的3种模型CC vs.TT(OR=0.72,95%CI:0.54-0.96)、CT vs.TT(OR=0.74,95%CI:0.58-0.94)和(CC+CT)vs.TT(OR=0.73,95%CI:0.58-0.91)有明显相关性,提示原发性不育的风险降低。而rs9340799基因2种模型AA vs.GG(OR=1.67,95%CI:1.21-2.32)和AA vs.(GA+GG)(OR=1.63,95%CI:1.32-2.03)也有明显相关性,提示男性不育的风险显著增加。结论:rs2234693 CC基因型可以降低男性不育的危险性,而rs9340799 AA基因型可能与男性不育相关。
Objective: To analysis the relationship between two polymorphism genes of estrogen receptor α rs2234693 and rs9340799 and male infertility by Meta-analysis. Methods: We searched Pub Med,EMABSE,CNKI and Wan Fang database,while 24 articles were concluded. Meta analysis was performed using Stata 11. 0 software. Calculated the odds ratio and 95% confidence interval and evaluated the strength of the associations,sensitivity and publication bias. Results: For the rs2234693,there were significant association in the comparison of CC vs. TT( OR = 0. 72,95% CI: 0. 54- 0. 96),CT vs. TT( OR = 0. 74,95% CI: 0. 58- 0. 94) and( CC + CT) vs. TT( OR = 0. 73,95% CI: 0. 58- 0. 91)with male infertility. For rs9340799 polymorphism,increased risks were observed for the comparison of AA vs. GG( OR = 1. 67,95% CI: 1. 21- 2. 32) and AA vs.( GA + GG)( OR = 1. 63,95% CI: 1. 32-2. 03). Conclusion: The rs2234693 CC genotype was associated with the decreased risk for male infertility; however,the rs9340799 AA genotype was associated with an increased risk for male infertility.
出处
《江苏大学学报（医学版）》
CAS
2015年第1期57-61,共5页
Journal of Jiangsu University：Medicine Edition
基金
江苏省科技专项基金资助项目(BM2013058)
