摘要
目的 通过超声测量 10～ 2 4孕周胎儿颈后皮肤的厚度 (NT)、双顶径 /股骨长度 (BPD/FL)的正常值 ,筛查出异常、可疑的病例 ,再作胎儿细胞培养染色体分析 ,诊断非整倍体染色体畸形胎儿。方法 对孕 10～ 2 4周的孕妇 ,通过B超测定胎儿孕囊大小或胎儿头臀长或胎儿BPD、FL和AC确定孕周 ,再测量NT、BPD/FL。每孕周测量 10 0例。分别绘制NT、BPD/FL正常曲线 ,制定出第 90和第 10百分位。回顾分析 5例 2 1-三体综合征。结果 孕 10～ 13周 ,正常NT平均值为 1 76mm ,孕 14～ 2 4周平均值3 5 2mm。孕 10～ 2 4周的孕妇 ,BPD/FL第 5 0百分位为 2 40～ 1 40。结论 达到或超过NT及BPD/FL比值相应孕周的第 90百分位 ,2
Objective To sonographically measure nuchal skin thickness(NT) and biparietal diameter/femur length (BPD/FL) for normal fetuses between 10 and 24 gestational weeks,screen abnormal cases then to culture fetal cells and chromosome analysis, diagnosis aneuploid chromosome deformed fetuses Methods Ultrosonic estimation of fetal gestation according to gestational sac or CRL or BPD/Fl and AC, measuring NT, BPD/Fl of 100 cases per gestational weeks, drawing normal curve of NT, making curve of 90 th and 10 th NT and BPD/Fl. Restropectively analysis 5 cases trisomy 21.Results The average of NT was 1 76mm between 10 and 13 gestational weeks. The average of NT was 3 52mm between14 and 24 gestational weeks. The value of 50th was 2 40～1 40 between14 and 24 gestational weeks.Conclusions If the value of NT is more than 90 percent of normal fetuses, and if BPD/FL ratio is morn than 90 percent of normal fetuses,the sensitivity of trisome 21 should increase.Combining factors as elderly and high risk parturition, the sensitivity of trisomy 21 is much more increasing.
出处
《中国医师杂志》
CAS
2003年第6期758-760,共3页
Journal of Chinese Physician
