摘要
目的探讨消化道恶性肿瘤患者血清红细胞生成素(EPO)水平的变化,分析EPO与贫血和临床病理特征的关系。方法用化学免疫发光法检测226例1293人次的消化道恶性肿瘤患者血清EPO水平,分析EPO与临床病理特征的相关性。结果消化道肿瘤患者红细胞平均血红蛋白浓度(MCHC)为(0.29±0.01)g/L,E P O水平为(52.25±129.64)IU/L。贫血和不贫血的肿瘤患者EPO有显著性差异(Z=-27.80,P<0.05,双侧)。不同程度贫血患者的EPO有显著性差异(X=126.26,P<0.01,双侧)。IV期患者和其他分期患者E P O水平分别为(60.05±141.43)IU/L和(21.80±28.69)IU/L,有显著性差异(X=52.47,P<0.01,双侧),血红蛋白浓度分别为(122.24±19.66)g/L和(130.98±16.95)g/L,有显著性差异(X=47.87,P<0.01,双侧)。消化道肿瘤患者化疗前后患者贫血程度及EPO水平无显著性差异。结论消化道恶性肿瘤贫血多为小细胞低色素性贫血。贫血肿瘤患者血清EPO水平异常增高,且肿瘤晚期和转移患者EPO水平增高更明显。分析化疗和贫血及EPO的关系还需要考虑更多相关因素。
Objective To investigate the clinical values of erythropoietin (EPO) in the patients with digestive tracts cancer in Guangdong General hospital. Methods 226 cases of digestive tracts cancer were analyzed, retrospectively. Results There are signiifcant differences of EPO between the groups with and without anemia in patients with digestive tracts cancers, while these patients with different degrees of anemia showed signiifcant differences in levels of EPO. Conclusions The EPO in patients with IV stage and metastasis usually had higher levels than that of earlier stage and without metastasis.
出处
《肿瘤代谢与营养电子杂志》
2015年第1期39-41,共3页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
广东省科技计划项目(2013B021800198)
关键词
红细胞生成素
肿瘤
贫血
消化道
Erythropoietin
Cancer
Anemia
Digestive tracts
