摘要
目的探讨Fascin和Wnt5a在卵巢上皮性癌中的表达及临床意义,分析两者表达的相关性。方法应用免疫组织化学法检测Fascin和Wnt5a在20例正常卵巢组织、16例卵巢良性肿瘤,18例卵巢交界性肿瘤和79例卵巢上皮性癌组织中的表达情况。结果 (1)Fascin在卵巢上皮性癌中的表达明显高于正常卵巢组织、卵巢良性肿瘤(P<0.01);在卵巢交界性肿瘤中Fascin的表达高于其在正常卵巢组织的表达(P<0.01);Fascin的表达与组织病理分级(P<0.05)、临床分期(P<0.05)以及淋巴转移(P<0.01)密切相关。(2)Wnt5a在卵巢上皮性癌中的表达明显低于正常卵巢组织、卵巢良性肿瘤(P<0.01);Wnt5a的表达与组织病理分级(P<0.01)、临床分期(P<0.01)以及淋巴转移(P<0.05)密切相关。(3)Fascin与Wnt5a在卵巢上皮性癌中的表达呈负相关(P=0.0000,r=-0.526)。结论 Fascin和Wnt5a可能在卵巢上皮性癌的发生、发展、预后过程中起重要作用。
Objective To observe the expression of Fascin and Wnt5 a in epithelial ovarian cancer and explore the correlation. Methods Immunohistochemical method was used to assess the expression of Fascin and Wnt5 a in 20 cases of normal ovarian tissues, 16 cases of benign ovarian tumors,18 cases of borderline ovarian tumors and 79 cases of epithelial ovarian cancer. Results The expression of Fascin protein in epithelial ovarian cancer was significantly lower than those in normal ovarian, benign ovarian and borderline ovarian tumor(P<0.01). The expression of Wnt5 a protein was closely related with histopathological grading(P<0.01), clinical stage(P<0.01) and lymph node metastasis(P<0.05). The expression of Fascin and Wnt5 a in epithelial ovarian cancer was negatively correlated(P=0.000,r=-0.526). Conclusion Fascin and Wnt5 a may play important roles in the occurrence, development and prognosis of epithelial ovarian cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2014年第10期1107-1110,共4页
Cancer Research on Prevention and Treatment
基金
陇原青年创新人才扶持计划[甘卫人函(2008)93号]
