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肿瘤发生发展中Mina53的作用机制 被引量：4

Mechanism of Mina53 in Tumorigenesis and Development
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摘要 c-Myc的下游靶基因Myc-induced nuclear antigen with a molecular mass of 53 k Da(Mina53)在多种肿瘤组织中异常表达,且与肿瘤临床分期、淋巴结转移及临床预后之间关系密切。Mina53可通过调控细胞分化、增殖、凋亡等参与肿瘤发生发展,但其相关作用机制还不十分清楚。为此,本文拟通过综述Mina53在肿瘤发生发展中的机制研究进展,探讨其在肿瘤治疗中的意义和价值。 Myc-induced nuclear antigen with a molecular mass of 53 k Da(Mina53), c-Myc downstream target gene, expresses abnormally in variety of tumor tissues, and has close relations with tumor clinical stages, lymph node metastasis and clinical prognosis. Mina53 is involved in tumorigenesis and development by regulating cell differentiation, proliferation, apoptosis, etc. However, the related mechanism is still not very clear. Therefore, this paper will review the research progress of mechanism of Mina53 in tumorigenesis and development and explore its significance and value in cancer therapy.
作者 孙元元(综述) 郭志 杨雪玲(审校)
机构地区 天津医科大学肿瘤医院介入治疗科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2015年第1期78-81,共4页 Cancer Research on Prevention and Treatment
基金 国家自然科学基金(81471761) 天津市抗癌重大专项攻关计划(12ZCDZSY17200)
关键词 MINA53 C-MYC 肿瘤 机制 Mina53 c-Myc Tumor Mechanism
分类号 R730.2 [医药卫生—肿瘤]
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参考文献21

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二级参考文献22

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共引文献4

同被引文献34

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肿瘤防治研究
2015年 第1期

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