期刊文献+

黑素瘤相关抗原-A9和-A11在食管鳞状细胞癌组织中的表达及其临床意义 被引量:8

Expression and clinical significance of melanoma antigen-A9 and-A11 in esophageal squamous cell caricinoma tissues
原文传递
导出
摘要 目的:探讨黑素瘤相关抗原(melanoma antigen,MAGE)-A9和-A11在食管鳞状细胞癌组织中的表达情况,分析其与食管癌患者临床病理学特征及其预后的关系。方法:选取河北医科大学第四医院2010年9月至2010年11月住院手术切除的食管癌组织及距癌组织边缘5 cm以上且病理诊断证实为正常组织的癌旁组织标本各60例,同时选取5例该院前列腺癌住院患者术后的睾丸组织作为阳性对照,应用免疫组织化学法检测食管鳞状细胞癌组织及相应癌旁组织中MAGE-A9和-A11蛋白的表达。结果:食管鳞状细胞癌组织中MAGE-A9和MAGE-A11蛋白的阳性表达率分别为45%(27/60)和66.67%(40/60),而相应的癌旁组织未发现MAGE-A9和-A11蛋白的表达。MAGE-A9蛋白的表达与食管鳞状细胞癌患者的年龄、临床分期、肿瘤大小、淋巴转移均无相关性(P>0.05),但与组织学分级相关(P<0.05);MAGE-A11蛋白表达与食管鳞状细胞癌患者的年龄、组织学分级、淋巴转移均无相关性(P>0.05),但与临床分期、肿瘤大小呈正相关(P<0.05)。Log-Rank检验显示,MAGE-A9(P=0.037)和-A11(P=0.039)蛋白表达阳性的食管鳞状细胞癌患者和贲门腺癌患者的生存期均显著低于其表达阴性的患者。Cox多因素分析提示,MAGE-A9(P=0.026)和MAGE-A11(P=0.038)蛋白表达、组织学分级(P=0.026)、临床分期(P=0.008)及淋巴结转移(P=0.010)可作为整体生存的独立预后因素。结论:MAGE-A9和-A11蛋白是食管鳞状细胞癌的特异性抗原,似可作为食管鳞状细胞癌预后不良的预测指标。 Objective: To investigate the expression of melanoma antigen( MAGE)-A9 and MAGE-A11 in esophageal squamous cell carcinomas in association with major clinical and biological variables. Methods: Cancerous( n = 60) and adjacent( n = 60) esophageal tissue specimens were collected from 60 patients with esophageal squamous cell carcinomas who underwent surgery in Hebei Medical University-Affiliated Fourth Hospital between September and November 2010.Testicular tissue specimens were collected from 5 prostate cancer patients in the same time as positive controls. MAGE-A9 and MAGE-A11 in these tissue specimens were assessed by immmuohistochemical staining. Correlations of MAGE-A9 and MAGE-A11 levels with patients’ major clinical and demographic variables were determined. Results: MAGE-A9 and-A11 were positive in 45%( 27 /60) and 66. 67%( 40 /60) of cancerous tissue specimens respectively but were both negative in tumor-adjacent tissue specimens. While MAGE-A9 protein was not correlated with age,clinical stage,tumor size,and lymph node metastasis( P > 0. 05),it was significantly correlated with the histological grade of the lesion in patients with esophageal squamous cell carcinoma( P < 0. 05). While MAGE-A11 protein was not correlated with age,histological grade,lymph node metastasis( P > 0. 05),it was significantly correlated with clinical stage and tumor size( P < 0. 05) in patients with esophageal squamous cell carcinoma. Log-rank test showed that the survival time was significantly shorter in MAGE-A9-positive( P = 0. 037) and MAGE-A11 positive( P = 0. 039) patients than in MAGE-A9-negative and MAGEA11-negative patients. Cox multivariate analysis suggested that MAGE-A9 protein( P = 0. 026),MAGE-A11 protein( P = 0. 038),histological grade( P = 0. 026),TNM stage( P = 0. 008) and lymph node metastasis( P = 0. 010) were independent prognostic factors for overall survival. Conclusion: MAGE-A9 and-A11 are esophageal squamous cell carcinoma-specific antigens,thus having potential diagnostic and prognostic significance in clinical settings.
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2015年第5期630-636,共7页 Chinese Journal of Cancer Biotherapy
基金 河北省财政支撑项目资助(No.[2012]2056) 河北省科技支撑计划项目资助(No.14277732D)~~
关键词 食管鳞状细胞癌 抗原 黑素瘤相关抗原-A9 黑素瘤相关抗原-A11 esophageal squamous cell carcinomas(ESCC) antigens melanoma antigen-A9 melanoma antigen-A11
  • 相关文献

参考文献21

  • 1John,T. et al.The role of Cancer-Testis antigens as predictive and prognostic markers innon-small cell lung cancer. PLOS ONE . 2013
  • 2P van der Bruggen,C Traversari,P Chomez,C Lurquin,E De Plaen,B Van den Eynde,A Knuth,T Bo.A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science . 1991
  • 3Chomez P,De Backer O,Bertrand M,et al.An overview of the MAGE gene family with the identification of all human members of the family. Cancer Research . 2001
  • 4Haier J,Owzcareck M,Guller U,Spagnoli G C,Bürger H,Senninger N,Kocher Th.Expression of MAGE-A cancer/testis antigens in esophageal squamous cell carcinomas. Anticancer Research . 2006
  • 5JacquesFerlay,Hai‐RimShin,FreddieBray,DavidForman,ColinMathers,Donald MaxwellParkin.??Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008(J)Int. J. Cancer . 2010 (12)
  • 6Vaccines for the treatment of non-small cell lung cancer: Investigational approaches and clinical experience(J)Lung Cancer . 2011 (1)
  • 7Yishui Lian,Meixiang Sang,Chunyan Ding,Xinliang Zhou,Xiaojie Fan,Yingying Xu,Weihua Lü,Baoen Shan.??Expressions of MAGE-A10 and MAGE-A11 in breast cancers and their prognostic significance: a retrospective clinical study(J)Journal of Cancer Research and Clinical Oncology . 2012 (3)
  • 8Chantal Mengus,Elke Schultz‐Thater,Julie Coulot,Zeljko Kastelan,Eleonora Goluza,Marijana Coric,Giulio C. Spagnoli,Tvrtko Hudolin.??MAGE‐A10 cancer/testis antigen is highly expressed in high‐grade non‐muscle‐invasive bladder carcinomas(J)Int. J. Cancer . 2012 (10)
  • 9Lee H S,Kim S W,Hong J C,et al.Expression of MAGE Al-6 and the clinical characteristics of papillary thyroid carcinoma. Anticancer Research . 2013
  • 10Irma Olarte,Adolfo Martinez,Christian Ramos-Penafiel.MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma. Hematology . 2011

二级参考文献31

  • 1梁锐,王芳,王开昕,高倩,王志强,杨耘.MAGE-A1,-A4基因在大肠肿瘤中的表达及临床意义[J].世界华人消化杂志,2005,13(5):657-661. 被引量:2
  • 2周迈,彭吉润,王红霞,钟朝辉,郭晏同,潘秀英,冷希圣.利用质谱技术对肝癌组织中自然呈递的MAGE表位进行鉴定[J].世界华人消化杂志,2005,13(12):1395-1399. 被引量:14
  • 3van der Bruggen P,Traversari C,Chomez P,Lurquin C,De Plaen E,Van den Eynde B,Knuth A,Boon T.A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.Science 1991;254:1643-1647
  • 4Eura M,Chikamatsu K.Ogi K,Nakano K,Masuyama K,Ishikawa T.Expression of genes MAGE-1,-2,and-3 by human maxillary carcinoma cells.Anticancer Res 1995;15:55-59
  • 5Chen CH,Huang GT,Lee HS,Yang PM,Yan MD,Chen DS,Sheu JC.High frequency of expression of MAGE genes in human hepatocellular carcinoma.Liver 1999;19:110-114
  • 6Brasseur F,Marchand M,Vanwijck R,Herin M,Lethe B,Chomez P,Boon T.Human gene MAGE-1,which codes for a tumor-rejection antigen,is expressed by some breast tumors.Int J Cancer 1992;52:839-841
  • 7Shichijo S,Tsunosue R,Masuoka K.Natori H,Tamai M,Miyajima J,Sagawa K,Itoh K.Expression of the MAGE gene family in human lymphocytic leukemia.Cancer Immunol Immunother 1995;41:90-103
  • 8Inoue H,Mori M,Honda M,Li J,Shibuta K,Mimori K,Ueo H,Akiyoshi T.The expression of tumorrejection antigen "MAGE" genes in human gastric carcinoma.Gastroenterology 1995;109:1522-1525
  • 9Gajjar NA,Cochran AJ,Binder SW.Is MAGE-1expression in metastatic malignant melanomas really helpful?Am J Surg Pathol 2004;28:883-888
  • 10Castelli C,Rivoltini L,Andreola G,Carrabba M,Renkvist N,Parmiani G.T-cell recognition of melanoma-associated antigens.J Cell Physiol 2000;182:323-331

共引文献63

同被引文献52

  • 1吉晓滨,苏娟,陈敬贤,谢景华.黑色素瘤抗原在喉癌中的表达及临床评价[J].中华临床医师杂志(电子版),2011,5(24):7271-7276. 被引量:7
  • 2李佳,潘林娜,张志燕,李曼.MAGE-A1在食管癌中的表达及其与肿瘤细胞增殖的关系[J].世界华人消化杂志,2007,15(7):706-711. 被引量:10
  • 3FERLAY J, SHIN H R, BRAY F, et al. Estimates of worldwide burden of cancerin 2008: GLOBOCAN 2008 [ J]. Int J Cancer, 2010, 127 (12) : 2893-2917. DOI: 10. 3410/[ 723871841. 793516570.
  • 4LINDSEY A T, FREDDIE B, REBECCA L S, et al. Global cancer statistics, 2012 [J]. CA, 2015, 65(2): 87-108. DOI: 10. 3322/caac. 21262.
  • 5VAN DER BRUGGEN P, TRAVERSARI C, CHOMEZ P, et al. A gene encoding an antigen recognized by cytolytic T lymphoeytes on a human melanoma [ J]. Science, 1991 (254) : 1643-1647. DOI : 10.1126/science. 1840703.
  • 6CHOMEZ P, DE BACKER O, BERTRAND M, et al. An over- view of the MAGE gene family with the identi? cation of all human members of the family [ J]. Cancer Res, 2001 (61) :5544-5551.
  • 7SIMPSON A J, CABALLERO O L, JUNGBLUTH A, et al. Canc- er/testis antigens, gametogenesis and cancer [ J ]. Nat Rev Cancer, 2005 (5): 615-625. DOI:10. 1038/nrc1669.
  • 8GUO L, SANG M, LIU Q, et al. The expression and clinical sig- nificance of melanoma-associated antigen-A1, -A3 and -All in glioma [J]. Oncol Lett, 2013, 6( 1 ): 55-62. DOI:10. 3892/ol. 2013. 1351.
  • 9HOU S Y, SANG M X, GENG C Z, et al. Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mecha- nism [J]. Arch Med Res, 2014, 45(1) : 44-51. DOI:10. 1016/ j. arcmed. 2013.10. 005.
  • 10LIU W H, SANG M X, HOU S Y, et al. Low-dose decitabine in- duces MAGE-A expression and inhibitsinvasion via suppression of NF-kB2 and MMP2 in Ecal09 ceils [ J ]. Biomed Pharmacother, 2014, 68(6) : 745-750. DOI:10. 1016/j. biopha. 2014.07. 013.

引证文献8

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部