期刊文献+

树突状细胞疫苗肿瘤抗原负载方式的临床转化研究进展 被引量:3

Research progress of clinical translation on tumor antigen delivery strategies of dendritic cell vaccine
原文传递
导出
摘要 树突状细胞(dendritic cell,DC)是体内功能最强的抗原提呈细胞,能将肿瘤抗原提呈给T细胞,是抗肿瘤免疫的启动者。DC疫苗的肿瘤免疫治疗虽已取得丰硕成果,但在其临床转化过程中还有很多问题需要解决,选择何种抗原负载方式则是其中之一。目前临床试验中常用的有肿瘤细胞裂解物负载DC、重组肿瘤相关抗原负载DC及携带肿瘤相关抗原信息的mRNA转染DC三种方法。本文对此三种方法在临床试验中的应用做一综述,为树突状细胞疫苗的临床应用提供参考。
机构地区 解放军第
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2015年第5期646-650,共5页 Chinese Journal of Cancer Biotherapy
基金 南京市科技发展计划项目(No.201303040)~~
  • 相关文献

参考文献50

  • 1Mu L J,Kyte J A,Kvalheim G,Aamdal S,Dueland S,Hauser M,Hammerstad H,Waehre H,Raabe N,Gaudernack G.Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients. British Journal of Cancer . 2005
  • 2Coosemans Ann,W?lfl Matthias,Berneman Zwi N,Van Tendeloo Viggo,Vergote Ignace,Amant Frédéric,Van Gool Stefaan W.Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma. Anticancer Research . 2010
  • 3Kantoff Philip W,Higano Celestia S,Shore Neal D,Berger E Roy,Small Eric J,Penson David F,Redfern Charles H,Ferrari Anna C,Dreicer Robert,Sims Robert B,Xu Yi,Frohlich Mark W,Schellhammer Paul F.Sipuleucel-T immunotherapy for castration-resistant prostate cancer. The New England Quarterly . 2010
  • 4Kondo Hiroshi,Hazama Shoichi,Kawaoka Toru,Yoshino Shigefumi,Yoshida Shin,Tokuno Kazuhisa,Takashima Motonari,Ueno Tomio,Hinoda Yuji,Oka Masaaki.Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Research . 2008
  • 5Nakamura Masafumi,Wada Junji,Suzuki Hiroyuki,Tanaka Masao,Katano Mitsuo,Morisaki Takashi.Long-term outcome of immunotherapy for patients with refractory pancreatic cancer. Anticancer Research . 2009
  • 6Boczkowski D,Nair S K,Snyder D,Gilboa E.Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. The Journal of experimental medicine . 1996
  • 7HidekiUeno,NathalieSchmitt,EynavKlechevsky,AlexanderPedroza‐Gonzalez,ToshimichiMatsui,GerardZurawski,SangKonOh,JosephFay,VirginiaPascual,JacquesBanchereau,KarolinaPalucka.??Harnessing human dendritic cell subsets for medicine(J)Immunological Reviews . 2010 (1)
  • 8Sébastien Anguille,Evelien L Smits,Eva Lion,Viggo F van Tendeloo,Zwi N Berneman.Clinical use of dendritic cells for cancer therapy[J]. Lancet Oncology . 2014 (7)
  • 9Ashish H. Shah,Amade Bregy,Deborah O. Heros,Ricardo J. Komotar,John Goldberg.??Dendritic Cell Vaccine for Recurrent High-Grade Gliomas in Pediatric and Adult Subjects: Clinical Trial Protocol(J)Neurosurgery . 2013 (5)
  • 10Mervat El Ansary,Sherif Mogawer,Samah Abd Elhamid,Sahr Alwakil,Fatma Aboelkasem,Hatem El Sabaawy,Olfat Abdelhalim.??Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC(J)Journal of Cancer Research and Clinical Oncology . 2013 (1)

共引文献12

同被引文献31

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部