期刊文献+

胃低分化腺癌患者术后组织中Bmi-1、激活蛋白-2γ和白细胞分化抗原147的表达及意义 被引量:2

下载PDF
导出
摘要 目的观察胃低分化腺癌患者术后组织中多梳基因Bmi-1、激活蛋白(AP)-2γ和白细胞分化抗原(CD)147的表达特征及临床意义。方法 123例胃低分化腺癌患者术后组织作为研究组,以87例距肿瘤边缘超过5 cm的正常胃黏膜组织作为对照组,采用免疫组化方法检测Bmi-1、AP-2γ和CD147的表达。结果研究组Bmi-1、AP-2γ和CD147表达阳性率明显高于对照组,研究组Bmi-1、AP-2γ和CD147表达阳性率与肿瘤浸润深度、淋巴结转移、脉管浸润、增殖指数均密切相关。研究组Bmi-1和AP-2γ表达呈正相关。结论胃低分化腺癌组织中Bmi-1、AP-2γ和CD147高表达对肿瘤的发生和进展有重要作用,Bmi-1和AP-2γ具有协同正向调节作用,术后联合检测Bmi-1、AP-2γ和CD147对判断肿瘤进展有一定意义。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第14期3900-3902,共3页 Chinese Journal of Gerontology
  • 相关文献

参考文献11

  • 1孟秀香,刘丹丹,聂慧玲,刘纯青,刘奔,赵宝霞,赵心宇,杨红.Bmi-1与MMP-2在肺腺癌组织中的表达及其临床意义[J].中国实验诊断学,2013,17(9):1587-1589. 被引量:5
  • 2王玹,张翔,倪斌,朱宏辉,赵帅,苏波,苏琦.AP-2γ在胃癌中表达的临床病理意义[J].中国医药指南,2013,11(9):1-3. 被引量:1
  • 3高玉宝,李常恩.应用组织芯片检测Bmi-1及P16在胆管细胞癌中的表达及意义[J].吉林医学,2014,35(8):1595-1597. 被引量:1
  • 4Xueyan Zhang,Jiayuan Sun,Huimin Wang,Yuqing Lou,Yanwei Zhang,Huifang Sha,Jiuxian Feng,Baohui Han.IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance[J].Tumor Biology.2014(1)
  • 5Jian Gao,Zhenhua Hu,Juanjuan Liu,Dawo Liu,Yanyan Wang,Mingbo Cai,Danye Zhang,Mingzi Tan,Bei Lin.Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance[J].Medical Oncology.2014(5)
  • 6童英,成元华,文安智.精原细胞瘤中M2A、AP-2γ、OCT3/4、PLAP和CD117的表达及其意义[J].实用医学杂志,2011,27(8):1338-1340. 被引量:3
  • 7Song, Li-Bing,Li, Jun,Liao, Wen-Ting,Feng, Yan,Yu, Chun-Ping,Hu, Li-Juan,Kong, Qing-Li,Xu, Li-Hua,Zhang, Xing,Liu, Wan-Li,Li, Man-Zhi,Zhang, Ling,Kang, Tie-Bang,Fu, Li-Wu,Huang, Wen-Lin,Xia, Yun-Fei,Tsao, Sai Wah,Li, Mengfeng,Band, Vimla,Band, Hamid,Shi, Qing-Hua,Zeng, Yi-Xin,Zeng, Mu-Sheng.The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells[J].Journal of Clinical Investigation.2009(12)
  • 8Yong‐Qing Tong,Bei Liu,Hong‐Yun Zheng,Yu‐Juan He,Jian Gu,Feng Li,Yan Li.Overexpression of BMI ‐1 is associated with poor prognosis in cervical cancer[J].Asia‐Pac J Clin Oncol.2012(4)
  • 9邹艳芳,田永,徐峰.Bmi-1和Mel-18基因在大肠癌组织中的表达及意义[J].世界华人消化杂志,2013,21(5):397-402. 被引量:27
  • 10Xiaolei Li,Zhaoxu Yang,Wenjie Song,Liang Zhou,Qingjun Li,Kaishan Tao,Jingshi Zhou,Xing Wang,Zhigang Zheng,Nan You,Kefeng Dou,Haimin Li.Overexpression of Bmi-1 contributes to the invasion and metastasis ofhepatocellular carcinoma by increasing the expression of matrix metalloproteinase(MMP)?2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway[J].International Journal of Oncology.2013(3)

二级参考文献73

共引文献86

同被引文献32

  • 1王晓琴,戴穹,杨志惠.bcl-2、Ki-67和bax蛋白在宫颈上皮内瘤变和宫颈癌中的表达及临床意义[J].中国医疗前沿(学术版),2008,3(1):27-28. 被引量:9
  • 2姜永冬,陈国林,娄春.胃低分化腺癌照射前后nm23蛋白的表达及其意义[J].哈尔滨医科大学学报,2005,39(3):253-255. 被引量:3
  • 3张洪海,李春德.胃粘膜活检中诊断低分化腺癌、粘液腺癌和粘液细胞癌的体会[J].诊断病理学杂志,1994,1(2):110-111. 被引量:6
  • 4Yuichi Segawa,Yoshinao Oda,Hidetaka Yamamoto,Hideki Shiratsuchi,Naoya Hirakawa,Shizuo Komune,Masazumi Tsuneyoshi.Close correlation between CXCR4 and VEGF expression and their prognosticimplications in nasopharyngeal carcinoma[J]. Oncology Reports . 2009 (5)
  • 5Zhu JM,Yu PW.Effects of Tiam-1on invasive capacity of gastric cancer cells in vitro and underlying mechanisms. Asian Pacific Journal of Cancer Prevention . 2013
  • 6Ghanem I,Riveiro ME,Paradis V et al.Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis. Am J Transl Res . 2014
  • 7Clatot F,Cornic M,Berghian A,et al.CXCL12 and CXCR4,but not CXCR7 are primarily expressed by the stroma in head and neck squamous cell carcinoma. The Journal of Pathology . 2015
  • 8Yerushalmi R,Woods R,Ravdin PM. Ki-67 in breast can- cer:prognostic and predictive potential [J]. Lancet Oncol, 2010, 11 (2) :74-83.
  • 9. Huh JW,Lee JH,Kim HR. Expression of p16,p53,and Ki- 67 in colorectal adenocarcinoma:a study of 356 surgically resected eases [J]. Hepatogastroenterology, 2010,57 ( 101 ) : 734-740.
  • 10Reya T, Morrison S J, Clarke MF, et al. Stem cells, cancer, and cancer stem cells [J]. Nature,2001,414(6859): 105-111.

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部