摘要
目的探讨蒙成药扎冲十三味丸对兔凝血机制的影响。方法选择20只新西兰大白兔为研究对象,给兔灌胃扎冲十三味丸28 d,检测给药前及给药后1 h、3 h、1 d、3 d、5 d、7 d、14 d、21 d、28 d各时间点兔血中凝血四项指标,并于给药后28 d检测血小板聚集率和黏附率,计算血小板聚集率和黏附率抑制率。结果与给药前比较,给药后凝血酶原时间、凝血酶时间、活化部分凝血活酶时间延长、纤维蛋白原减少,血小板聚集率和黏附率减少。结论扎冲十三味丸通过抗凝、抗血小板聚集和黏附,有抑制凝血作用。
Objective To investigate the effect of Mongolian official drug Zhachong Shisan Wei Pill on blood coagulation mechanism of rabbit.Methods The rabbits were treated with Zhachong Shisan Wei Pill via intragastric administration for 28 days.The four indexes of blood coagulation ,platelet aggregation fraction and adhesion fraction of rabbits'blood before and after the treatment 1 h,3 h,1 d,3 d,5 d, 7 d,14 d,21 d,28 d were detected and its inhibition ratio for the platelet aggregation and adhesion was evaluated.Results The prothrombin time,thrombin time and activated partial thromboplastin time of rabbits'blood after the treatment were lengthened while the concentration of blood fibrinogen ,platelet aggregation fraction and adhesion fraction were decreased.Conclusions Zhachong Shisan Wei Pill could inhibit the blood coagulation via anticoagulation and reducing platelet aggregation and adhesion .
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2014年第17期4910-4911,共2页
Chinese Journal of Gerontology
基金
内蒙古自治区教育厅研究项目(NJZY11204)
内蒙古自然科学基金项目(2011MS1170
2012MS1211)
内蒙古自治区卫生厅项目(2010182)
关键词
扎冲十三味丸
凝血机制
Zhachong Shisan Wei Pill
Coagulation mechanism
