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氯沙坦改善心力衰竭患者心功能的作用及对NO、ET、PGI_2水平的影响 被引量:5

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摘要 目的探讨氯沙坦治疗对心脏功能的改善及其对一氧化氮(NO)、内皮素(ET)、前列环素I2(PGI2)的影响。方法 96例患者随机分为氯沙坦组和常规治疗对照组,分别给予常规治疗和加用氯沙坦治疗12 w后,检测心功能参数以及血清中NO、ET、PGI2水平。结果心功能参数较治疗前好转(P<0.05),心衰患者NO、ET表达显著高于健康组,PGI2水平低于健康组,经过氯沙坦治疗后,NO、ET水平比治疗前明显降低,PGI2明显回升(P<0.05)。结论氯沙坦通过调节NO、ET及PGI2水平,增加心输出量而改善心功能。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第20期5655-5656,共2页 Chinese Journal of Gerontology
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